Evidence map›Paper›PMID 31810487›Full record

Observational studyCritical care (London, England)2019

Risk factors for the development of acute respiratory distress syndrome in mechanically ventilated adults in Peru: a multicenter observational study.

Ena Gupta, Shakir Hossen, Matthew R Grigsby, Phabiola Herrera, Rollin Roldan, Enrique Paz, Amador A Jaymez, Eduardo E Chirinos, Jose Portugal, Rocio Quispe and 3 more

Open access · goldAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Critical care (London, England), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 44 citations in OpenAlex.

  1. Review
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  6. Prognostic performance of the Age, PaOTherapeutic advances in infectious disease
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Ena GuptaDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, 1830 E. Monument St, Room 555, Baltimore, MD, 21287, USA.
Shakir HossenDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, 1830 E. Monument St, Room 555, Baltimore, MD, 21287, USA.
Matthew R GrigsbyDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, 1830 E. Monument St, Room 555, Baltimore, MD, 21287, USA.
Phabiola HerreraDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, 1830 E. Monument St, Room 555, Baltimore, MD, 21287, USA.
Rollin RoldanServicio de Cuidados Intensivos, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.
Enrique PazServicio de Cuidados Intensivos, Hospital Nacional Guillermo Almenara Irigoyen, Lima, Peru.
Amador A JaymezServicio de Cuidados Intensivos, Hospital Nacional Arzobispo Loayza, Lima, Peru.
Eduardo E ChirinosServicio de Cuidados Intensivos, Hospital De Emergencias José Casimiro Ulloa, Lima, Peru.
Jose PortugalServicio de Cuidados Intensivos, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.
Rocio QuispeServicio de Cuidados Intensivos, Hospital Nacional Edgardo Rebagliati Martins, Lima, Peru.
Roy G BrowerDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, 1830 E. Monument St, Room 555, Baltimore, MD, 21287, USA.
William CheckleyDivision of Pulmonary and Critical Care, School of Medicine, Johns Hopkins University, 1830 E. Monument St, Room 555, Baltimore, MD, 21287, USA. wcheckl1@jhmi.edu.ORCID 0000-0003-1106-8812
INTENSIVOS Cohort Study
Johns Hopkins University · USHospital Nacional Cayetano Heredia · PEHospital Base Guillermo Almenara Irigoyen · PEHospital de Emergencias Jose Casimiro Ulloa · PE

Funding

Acute Lung Injury: Application of Novel Approaches to Longitudinal Data AnalysisR00HL096955 · NHLBI · JOHNS HOPKINS UNIVERSITY · PI CHECKLEY, WILLIAM · 2011 to 2013
$723k
NHLBI NIH HHS R00 HL096955NIH HHS R00HL096955
6 · The paper itself

Abstract

backgroundClinical and epidemiological differences between acute respiratory distress syndrome (ARDS) that presents at the initiation of mechanical ventilation [MV] (ARDS at MV onset) and that which develops during the course of MV (ARDS after MV onset) are not well understood. We conducted an observational study in five Peruvian ICUs to characterize differences between ARDS at MV onset and after MV onset and identify risk factors for the development of ARDS after MV onset.

methodsWe consecutively enrolled critically ill patients with acute respiratory failure requiring at least 24 h of mechanical ventilation and followed them prospectively during the first 28 days and compared baseline characteristics and clinical outcomes by ARDS status.

resultsWe enrolled 1657 participants on MV (mean age 60.0 years, 55% males) of whom 334 (20.2%) had ARDS at MV onset and 180 (10.9%) developed ARDS after MV onset. Average tidal volume at the initiation of MV was 8.7 mL/kg of predicted body weight (PBW) for participants with ARDS at MV onset, 8.6 mL/kg PBW for those who developed ARDS after MV onset, and 8.5 mL/kg PBW for those who never developed ARDS (p = 0.23). Overall, 90-day mortality was 56% and 55% for ARDS after MV onset and ARDS at MV onset, respectively, as compared to 46% among those who never developed ARDS (p < 0.01). Adults with ARDS had a higher body mass index (BMI) than those without ARDS (27.3 vs 26.5 kg/m

conclusionsIn this study of mechanically ventilated patients, 31% of study participants had ARDS at some point during their ICU stay. Optimal lung-protective ventilation was not used in a majority of patients. Patients with ARDS after MV onset had a similar 90-day mortality as those with ARDS at MV onset. Higher airway pressures at MV onset, higher PEEP, and higher BMI were associated with the development of ARDS after MV onset.

Indexed as

AdultAgedAged, 80 and overFemaleHumansIntensive Care UnitsMaleMiddle AgedPeruProspective StudiesRespiration, ArtificialRespiratory Distress SyndromeRisk FactorsAcute respiratory distress syndromeCritically illMechanical ventilationPrevention

Identifiers

PMID31810487
PMCPMC6898929
OpenAlexW2993250205

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.