Evidence map›Paper›PMID 31810473›Full record

ArticleLipids in health and disease2019

Association of FTO common variant (rs9939609) with body fat in Turkish individuals.

Duygu Ağagündüz, Makbule Gezmen-Karadağ

Open access · goldAbstract read
In one paragraph

Article in Lipids in health and disease, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 33 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
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  5. Article
  6. Genetic variant rs9939609 inBMJ open diabetes research & care · 2023
    Observational
  7. Review
  8. Minor alleles in theNutrition research and practice · 2023
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Duygu AğagündüzDepartment of Nutrition and Dietetics, Emniyet Mahallesi, Muammer Yaşar Bostancı Caddesi, Gazi University Faculty of Health Sciences,, No:16, 06500 Beşevler, Ankara, Turkey.ORCID http://orcid.org/0000-0003-0010-0012
Makbule Gezmen-KaradağDepartment of Nutrition and Dietetics, Emniyet Mahallesi, Muammer Yaşar Bostancı Caddesi, Gazi University Faculty of Health Sciences,, No:16, 06500 Beşevler, Ankara, Turkey. mgezmenkaradag@gmail.com.ORCID http://orcid.org/0000-0003-3202-3250
Gazi Hastanesi · TRGazi University · TR

Funding

Gazi Üniversitesi 47/2017-05
6 · The paper itself

Abstract

backgroundVariations in the fat mass and obesity-associated (FTO) gene (16q12.2) are associated with obesity in some populations. This study aimed to determine the relationship between FTO gene polymorphism and adiposity&related markers in Turkish adults was aimed.

methodsThe present study included 200 participants aged 18-65 years, who were genotyped for variants of the FTO gene (rs9939609). Anthropometric measurements were performed. Body compositions were analyzed with Tanita BC 545 N Inner ScanTM. Infrared analyzer (VISCANTM) was also used to determinate the degree of abdominal fat. Body mass index (BMI), body adiposity index (BAI) and lipid accumulation products (LAP) index which are used in body fat estimation were calculated. Body fat amounts were classified using gender-based cut-offs. Odds ratio (OR) and 95% confidence interval (CI) were calculated to determine the risk of having a high body fat amount associated with the risk allele.

resultsThe frequency of the rs9939609 AA genotype was 19.0%, which was 42.5% for the AT genotype and 38.5% for the TT genotype (wild type). AA genotype was found to be higher in females than in males (26.0 and 12.0%, respectively). The total body fat amount of the individuals with AA genotype was high (28.5 ± 9.25%) compared to AT (27.0 ± 10.31%) and TT (23.7 ± 10.62%) genotype (p < 0.05). However, there was no difference in abdominal fat amounts (%) (AA:38.6%, AT:36.2%, TT:33.7%), internal fat levels and waist/hip ratios (p > 0.05). Significance of association between FTO genotypes and total body fat (%) was retained after adjustment for BMI and gender as well. BMI, LAP, and BAI index values were not different between different genotypes in all individuals and different genders (p > 0.05).

conclusionOur study supports that the FTO rs9939609 polymorphism is associated with fat accumulation in the whole body without being associated with abdominal fat accumulation in Turkish adults.

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAbdominal FatAdipose TissueAdolescentAdultAgedAllelesAlpha-Ketoglutarate-Dependent Dioxygenase FTOBody CompositionBody Mass IndexFemaleGene ExpressionGene FrequencyHumansMaleAlpha-Ketoglutarate-Dependent Dioxygenase FTOFTO protein, humanAdiposityFTOrs9939609

Identifiers

PMID31810473
PMCPMC6896279
OpenAlexW2994095521

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.