Evidence map›Paper›PMID 31810352›Full record

ArticleInternational journal of molecular sciences2019

Thermoresponsive Catechol Based-Polyelectrolyte Complex Coatings for Controlled Release of Bortezomib.

Berthold Reis, David Vehlow, Tarik Rust, Dirk Kuckling, Martin Müller

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Berthold ReisLeibniz-Institut für Polymerforschung Dresden e.V., Department Polyelectrolytes and Dispersions, Hohe Straße 6, 01069 Dresden, Germany.
David VehlowLeibniz-Institut für Polymerforschung Dresden e.V., Department Polyelectrolytes and Dispersions, Hohe Straße 6, 01069 Dresden, Germany.
Tarik RustUniversität Paderborn, Department of Chemistry, Warburger Str. 100, 33106 Paderborn, Germany.
Dirk KucklingUniversität Paderborn, Department of Chemistry, Warburger Str. 100, 33106 Paderborn, Germany.ORCID 0000-0001-6003-151X
Martin MüllerLeibniz-Institut für Polymerforschung Dresden e.V., Department Polyelectrolytes and Dispersions, Hohe Straße 6, 01069 Dresden, Germany.ORCID 0000-0001-8961-4604
Leibniz Institute of Polymer Research · DEPaderborn University · DE

Funding

Deutsche Forschungsgemeinschaft Project number 107540325 - TRR 79, project M7
6 · The paper itself

Abstract

To overcome the high relapse rate of multiple myeloma (MM), a drug delivery coating for functionalization of bone substitution materials (BSM) is reported based on adhesive, catechol-containing and stimuli-responsive polyelectrolyte complexes (PECs). This system is designed to deliver the MM drug bortezomib (BZM) directly to the anatomical site of action. To establish a gradual BZM release, the naturally occurring caffeic acid (CA) is coupled oxidatively to form poly(caffeic acid) (PCA), which is used as a polyanion for complexation. The catechol functionalities within the PCA are particularly suitable to form esters with the boronic acid group of the BZM, which are then cleaved in the body fluid to administer the drug. To achieve a more thorough control of the release, the thermoresponsive poly(

Indexed as

Drug Delivery SystemsBortezomibCaffeic AcidsCatecholsCoated Materials, BiocompatibleDelayed-Action PreparationsHumansMethacrylatesMultiple MyelomaPolyelectrolytesPolymers2-(dimethylamino)ethyl methacrylateBortezomibcaffeic acidCaffeic AcidscatecholCatecholsCoated Materials, BiocompatibleDelayed-Action PreparationsMethacrylatesPolyelectrolytesPolymersbortezomibcatechol chemistrycontrolled releasemultiple myelomapoly(caffeic acid)polyelectrolyte complex coatingsthermoresponsive coatings

Identifiers

PMID31810352
PMCPMC6928965
OpenAlexW2993465415

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.