Evidence map›Paper›PMID 31810328›Full record

Trial reportGenes2019

D-loop Mutations in Renal Cell Carcinoma Improve Predictive Accuracy for Cancer-Related Death by Integrating with Mutations in the

Hakushi Kim, Tomoyoshi Komiyama, Masahiro Nitta, Yoshiaki Kawamura, Masanori Hasegawa, Sunao Shoji, Yasushi Orihashi, Chie Inomoto, Hiroshi Kajiwara, Naoya Nakamura and 2 more

Open access · goldAbstract readClinical Trial
In one paragraph

Trial report in Genes, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Roles of MT-ND1 in Cancer.Current medical science · 2023
    Review
  5. Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Hakushi KimDepartment of Urology, Tokai University School of Medicine, Kanagawa, Isehara 259-1193, Japan.
Tomoyoshi KomiyamaDepartment of Clinical Pharmacology, Tokai University School of Medicine, Kanagawa, Isehara 259-1193, Japan.
Masahiro NittaDepartment of Urology, Tokai University School of Medicine, Kanagawa, Isehara 259-1193, Japan.
Yoshiaki KawamuraDepartment of Urology, Tokai University School of Medicine, Kanagawa, Isehara 259-1193, Japan.
Masanori HasegawaDepartment of Urology, Tokai University School of Medicine, Kanagawa, Isehara 259-1193, Japan.
Sunao ShojiDepartment of Urology, Tokai University School of Medicine, Kanagawa, Isehara 259-1193, Japan.
Yasushi OrihashiDepartment of Clinical Pharmacology, Tokai University School of Medicine, Kanagawa, Isehara 259-1193, Japan.
Chie InomotoDepartment of Pathology, Tokai University School of Medicine, Kanagawa, 259-1193 Isehara, Japan.
Hiroshi KajiwaraDepartment of Pathology, Tokai University School of Medicine, Kanagawa, 259-1193 Isehara, Japan.
Naoya NakamuraDepartment of Pathology, Tokai University School of Medicine, Kanagawa, 259-1193 Isehara, Japan.
Hiroyuki KobayashiDepartment of Clinical Pharmacology, Tokai University School of Medicine, Kanagawa, Isehara 259-1193, Japan.
Akira MiyajimaDepartment of Urology, Tokai University School of Medicine, Kanagawa, Isehara 259-1193, Japan.
Tokai University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Renal cell carcinoma (RCC) is associated with various genetic alterations. Although whole-genome/exome sequencing analysis has revealed that nuclear genome alterations are associated with clinical outcomes, the association between nucleotide alterations in the mitochondrial genome and RCC clinical outcomes remains unclear. In this study, we analyzed somatic mutations in the mitochondrial D-loop region, using RCC samples from 61 consecutive patients with localized RCC. Moreover, we analyzed the relationship between D-loop mutations and

Indexed as

Carcinoma, Renal CellKidney NeoplasmsMutationAdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansMaleMiddle AgedNADH DehydrogenaseNeoplasm ProteinsPredictive Value of TestsSurvival RateNADH DehydrogenaseNADH dehydrogenase subunit 1, humanNeoplasm Proteinscancer-specific survivalD-loop mutationsmitochondrial DNANADH dehydrogenase subunit 1prognostic factorrenal cell carcinoma

Identifiers

PMID31810328
PMCPMC6947453
OpenAlexW2990570671

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.