Evidence map›Paper›PMID 31810314›Full record

ArticleMolecules (Basel, Switzerland)2019

Insights into the Discovery of Novel Neuroprotective Agents: A Comparative Study between Sulfanylcinnamic Acid Derivatives and Related Phenolic Analogues.

Daniel Chavarria, Carlos Fernandes, Brandon Aguiar, Tiago Silva, Jorge Garrido, Fernando Remião, Paulo J Oliveira, Eugenio Uriarte, Fernanda Borges

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Daniel ChavarriaCIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
Carlos FernandesCIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID 0000-0002-0102-0703
Brandon AguiarCIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
Tiago SilvaCIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.
Jorge GarridoDepartment of Chemical Engineering, School of Engineering (ISEP), Polytechnic of Porto, 4200-072 Porto, Portugal.
Fernando RemiãoUCIBIO-REQUIMTE, Laboratory of Toxicology, Department of Biological Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal.ORCID 0000-0003-1382-5119
Paulo J OliveiraCNC-Center for Neuroscience and Cell Biology, University of Coimbra, UC Biotech, Biocant Park, 3060-197 Cantanhede, Portugal.ORCID 0000-0002-5201-9948
Eugenio UriarteDepartamento de Química Orgánica, Facultad de Farmacia, 15782 Santiago de Compostela, Spain.
Fernanda BorgesCIQUP/Department of Chemistry and Biochemistry, Faculty of Sciences, University of Porto, 4169-007 Porto, Portugal.ORCID 0000-0003-1050-2402
Universidade do Porto · PTBiocant · PTPolytechnic Institute of Porto · PTUniversidade de Santiago de Compostela · ES

Funding

Foundation for Science and Technology (FCT) and FEDER/COMPETE research grants UID/QUI/00081, NORTE-01-0145-FEDER-000028, POCI-01-0145-FEDER-029164)
6 · The paper itself

Abstract

Exogenous antioxidants may be beneficial therapeutic tools to tackle the oxidative damage in neurodegenerative diseases by regulation of the redox state that is critical for cell viability and organ function. Inspired by natural plant polyphenols, a series of cinnamic acid-based thiophenolic and phenolic compounds were synthesized and their antioxidant and neuroprotective properties were studied. In general, our results showed that the replacement of the hydroxyl group (OH) by a sulfhydryl group (SH) increased the radical scavenging activity and enhanced the reaction rate with 1,1-diphenyl-2-picrylhydrazyl radical (DPPH

Indexed as

Drug DiscoveryAntioxidantsCell Line, TumorChemical PhenomenaCinnamatesFree Radical ScavengersHumansMolecular StructureNeuroprotective AgentsOxidation-ReductionPhenolsStructure-Activity RelationshipSulfhydryl CompoundsAntioxidantsCinnamatescinnamic acidFree Radical ScavengersNeuroprotective AgentsPhenolsSulfhydryl Compoundsthiophenol4-thioferulic acid derivativesantioxidant activitycinnamic acidcytotoxicityferulic acid derivativesneuroprotection

Identifiers

PMID31810314
PMCPMC6930627
OpenAlexW2991412477

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.