Evidence map›Paper›PMID 31810243›Full record

ArticleCancers2019

The Landscape of Long Non-Coding RNA Dysregulation and Clinical Relevance in Muscle Invasive Bladder Urothelial Carcinoma.

Haotian Shen, Lindsay M Wong, Wei Tse Li, Megan Chu, Rachel A High, Eric Y Chang, Jessica Wang-Rodriguez, Weg M Ongkeko

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Haotian ShenDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, CA 92093, USA.
Lindsay M WongDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, CA 92093, USA.
Wei Tse LiDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, CA 92093, USA.
Megan ChuDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, CA 92093, USA.
Rachel A HighDepartment of Radiology, University of California San Diego, La Jolla, CA 92093, USA.
Eric Y ChangDepartment of Radiology, University of California San Diego, La Jolla, CA 92093, USA.
Jessica Wang-RodriguezDepartment of Pathology, University of California San Diego, La Jolla, CA 92093, USA.
Weg M OngkekoDepartment of Otolaryngology-Head and Neck Surgery, University of California San Diego, La Jolla, CA 92093, USA.
University of California, San Diego · USVA San Diego Healthcare System · US

Funding

Academic Senate of the University of California San Diego RS167R-ONGKEKO
6 · The paper itself

Abstract

Bladder cancer is one of the most common cancers in the United States, but few advancements in treatment options have occurred in the past few decades. This study aims to identify the most clinically relevant long non-coding RNAs (lncRNAs) to serve as potential biomarkers and treatment targets for muscle invasive bladder cancer (MIBC). Using RNA-sequencing data from 406 patients in The Cancer Genome Atlas (TCGA) database, we identified differentially expressed lncRNAs in MIBC vs. normal tissues. We then associated lncRNA expression with patient survival, clinical variables, oncogenic signatures, cancer- and immune-associated pathways, and genomic alterations. We identified a panel of 20 key lncRNAs that were most implicated in MIBC prognosis after differential expression analysis and prognostic correlations. Almost all lncRNAs we identified are correlated significantly with oncogenic processes. In conclusion, we discovered previously undescribed lncRNAs strongly implicated in the MIBC disease course that may be leveraged for diagnostic and treatment purposes in the future. Functional analysis of these lncRNAs may also reveal distinct mechanisms of bladder cancer carcinogenesis.

Indexed as

bladder carcinomalncRNA-protein interactionlncRNAsTCGA

Identifiers

PMID31810243
PMCPMC6966549
OpenAlexW2990818953

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.