Evidence map›Paper›PMID 31810183›Full record

ArticleJournal of clinical medicine2019

Evaluation of Point Shear Wave Elastography Using Acoustic Radiation Force Impulse Imaging for Longitudinal Fibrosis Assessment in Patients with HBeAg-Negative HBV Infection.

Christiana Graf, Antonia Mondorf, Viola Knop, Kai-Henrik Peiffer, Julia Dietz, Julia Friess, Heiner Wedemeyer, Peter Buggisch, Stefan Mauss, Thomas Berg and 13 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.0field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors at 10 institutions in 2 countries.

Christiana GrafDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Antonia MondorfDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Viola KnopDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Kai-Henrik PeifferDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Julia DietzDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Julia FriessDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Heiner WedemeyerDepartment of Gastroenterology, Hepatology and Endocrinology, Hannover Medical School, 30625 Hannover, Germany.
Peter BuggischInstitute for Interdisciplinary Medicine IFI, 20099 Hamburg, Germany.
Stefan MaussCenter for HIV and Hepatogastroenterology, 40237 Düsseldorf, Germany.
Thomas BergDepartment of Gastroenterology and Rheumatology, University Hospital Leipzig, 04103 Leipzig, Germany.ORCID 0000-0003-0003-6241
Michael RauschPractice of Internal Medicine, 10777 Berlin, Germany.
Martin SprinzlDepartment of Internal Medicine I, University Medical Centre of the Johannes Gutenberg-University, 55131 Mainz, Germany.
Hartwig KlinkerDepartment of Medicine II, Division of Hepatology, University Hospital Würzburg, 97080 Würzburg, Germany.ORCID 0000-0001-7140-6786
Holger HinrichsenGastroenterology-Hepatology Center, 24105 Kiel, Germany.
Jean-Pierre BronowickiHepato-Gastroenterology, Hopital Brabois- CHU Nancy, 54500 Vandoeuvre-les-Nancy, France.
Sebastian HaagPractice of Gastroenterology, 65189 Wiesbaden, Germany.
Dietrich HüppePractice of Hepatology, 44623 Herne, Germany.
Thomas LutzInfektiologikum, 60596 Frankfurt, Germany.
Thierry PoynardBioPredictive, 75007 Paris, France.
Stefan ZeuzemDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Mireen Friedrich-RustDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Christoph SarrazinDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Johannes VermehrenDepartment of Internal Medicine 1, University Hospital Frankfurt, 60596 Frankfurt, Germany.
Goethe University Frankfurt · DEBiopredic (France) · FRCenter for HIV and Hepatogastroenterology · DECentre Hospitalier Régional et Universitaire de Nancy · FRClinical Research Center Kiel · DEInstitute for Interdisciplinary Medicine · DEJohannes Gutenberg University Mainz · DEMedizinische Hochschule Hannover · DEUniversitätsklinikum Würzburg · DEUniversity Hospital Leipzig · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccurate assessment of hepatic fibrosis in patients with chronic HBeAg-negative Hepatitis B is of crucial importance not only to predict the long-term clinical course, but also to evaluate antiviral therapy indication. The aim of this study was to prospectively assess the utility of point shear wave elastography (pSWE) for longitudinal non-invasive fibrosis assessment in a large cohort of untreated patients with chronic HBeAg-negative hepatitis B virus (HBV) infection.

methods407 consecutive patients with HBeAg-negative HBV infection who underwent pSWE, transient elastography (TE) as well as laboratory fibrosis markers, including fibrosis index based on four factors (FIB-4), aspartate to platelet ratio index (APRI) and FibroTest, on the same day were prospectively followed up for six years. Patients were classified into one of the three groups: inactive carriers (IC; HBV-DNA <2000 IU/mL and ALT <40 U/L); grey zone group 1 (GZ-1; HBV DNA <2000 IU/mL and ALT >40 U/L); grey zone group 2 (GZ-2; HBV-DNA >2000 IU/mL and ALT <40 U/L).

resultspSWE results were significantly correlated with TE (r = 0.29,

conclusionOur data indicate that pSWE could be useful for non-invasive fibrosis assessment and follow-up in patients with HBeAg-negative chronic HBV infection.

Indexed as

acoustic radiation force impulse imagingAPRIFIB-4fibrotestHBVnon-invasive fibrosis assessmentpoint shear wave elastographytransient elastography

Identifiers

PMID31810183
PMCPMC6947378
OpenAlexW2990939432

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.