Evidence map›Paper›PMID 31810154›Full record

ArticleInternational journal of molecular sciences2019

An Ancient Mutation in the

Chenhui Liu, Xunping Jiang, Guiqiong Liu, Teketay Wassie, Shishay Girmay

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 8 citations in OpenAlex.

  1. Article
  2. Genetics and pathogenesis of scoliosis.North American Spine Society journal · 2024
    Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Chenhui LiuLaboratory of Small Ruminant Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Xunping JiangLaboratory of Small Ruminant Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Guiqiong LiuKey Laboratory of Agricultural Animal Genetics, Breeding and Reproduction of the Ministry of Education, Wuhan 430070, China.ORCID 0000-0003-3688-5958
Teketay WassieLaboratory of Small Ruminant Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.
Shishay GirmayLaboratory of Small Ruminant Genetics, Breeding and Reproduction, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China.ORCID 0000-0002-7999-9931
Ministry of Education of the People's Republic of China · CN

Funding

China Agricultural Research System CARS-38National Key R&D Program of China 2018YFD0502105
6 · The paper itself

Abstract

The reproductive rhythm undergoes several changes during the evolution of mammals to adapt to local environmental changes. Although the critical roles of melatonin (MLT) in the formation of reproductive rhythm have been well established, the genetic basis for the changes of reproductive rhythm remains uncertain. Here, we constructed the phylogenetic trees of 13 melatonin synthesis, metabolism and receptor genes, estimated their divergence times, and calculated their selection pressures. Then, we evaluated the effect of positively selected and functionally related mutations on protein activity. Our results showed that there were significant positive selection sites in the three major genes, including tryptophan hydroxylase 1 (

Indexed as

Evolution, MolecularSelection, GeneticAllelesAnimalsCircadian RhythmHumansIndoleamine-Pyrrole 2,3,-DioxygenaseMammalsMelatoninMutationPhylogenyPolymorphism, GeneticProtein ConformationReceptors, MelatoninReproductionTryptophan HydroxylaseIDO1 protein, humanIndoleamine-Pyrrole 2,3,-DioxygenaseMelatoninReceptors, MelatoninTPH1 protein, humanTPH2 protein, humanTryptophan Hydroxylasefunctional diversificationmelatonin-related genespositive selectionreproductive rhythm

Identifiers

PMID31810154
PMCPMC6928614
OpenAlexW2990976936

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.