Evidence map›Paper›PMID 31809943›Full record

ArticleJournal of psychiatric research2020

Neurocognitive markers of childhood abuse in individuals with PTSD: Findings from the INTRuST Clinical Consortium.

Jessica Bomyea, Alan N Simmons, Martha E Shenton, Michael J Coleman, Sylvain Bouix, Yogesh Rathi, Ofer Pasternak, Raul Coimbra, Lori Shutter, Mark S George and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatric research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Article
  3. The effects of sexual abuse on female adolescent brain structures.Scandinavian journal of child and adolescent psychiatry and psychology · 2023
    Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Jessica BomyeaCenter of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA. Electronic address: jbomyea@ucsd.edu.
Alan N SimmonsCenter of Excellence for Stress and Mental Health, VA San Diego Healthcare System, San Diego, CA, 92161, USA; Department of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA.
Martha E ShentonPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston St, Boston, MA, 02215, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA; VA Boston Healthcare System, Brockton Division, Brockton, MA, 02301, USA.
Michael J ColemanPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston St, Boston, MA, 02215, USA.
Sylvain BouixPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston St, Boston, MA, 02215, USA.
Yogesh RathiPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston St, Boston, MA, 02215, USA.
Ofer PasternakPsychiatry Neuroimaging Laboratory, Department of Psychiatry, Brigham and Women's Hospital, Harvard Medical School, 1249 Boylston St, Boston, MA, 02215, USA; Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
Raul CoimbraDepartment of Surgery, University of California San Diego, La Jolla, CA, 92161, USA.
Lori ShutterUniversity of Pittsburgh School of Medicine, Pittsburgh, PA, 15261, USA.
Mark S GeorgeMedical University of South Carolina, Ralph H. Johnson VA Medical Center, Charleston, SC, 29401, USA; Ralph H. Johnson VA Medical Center, Charleston, SC, 29401, USA.
Gerald GrantStanford University Medical Center, Palo Alto, CA, 94305, USA; Duke University, Durham, NC, 90586, USA.
Ross D ZafonteSpaulding Rehabilitation Hospital, Massachusetts General Hospital, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, 02215, USA.
Thomas W McAllisterGeisel School of Medicine at Dartmouth, Hanover, NH, 03755, USA; Indiana University School of Medicine, Indianapolis, IN, 46202, USA.
Murray B SteinDepartment of Psychiatry, University of California San Diego, La Jolla, CA, 92093, USA; University of California, San Diego Department of Family Medicine and Public Health, La Jolla, CA, 92093, USA.
INTRuST consortium

Funding

CRCNS:Subject-Specific Difusion MRI Profiles of Injury in TBI and PTSDR01HD090641 · NICHD · BRIGHAM AND WOMEN'S HOSPITAL · PI BOUIX, SYLVAIN · 2016 to 2018
$810k
Cognitive Training as a Novel Neuroscience-based Treatment for PTSDIK2CX001600 · VA · VA SAN DIEGO HEALTHCARE SYSTEM · PI BOMYEA, JESSICA · 2018 to 2023
–
CSRD VA IK2 CX001600NICHD NIH HHS R01 HD090641
6 · The paper itself

Abstract

To date, few studies have evaluated the contribution of early life experiences to neurocognitive abnormalities observed in posttraumatic stress disorder (PTSD). Childhood maltreatment is common among individuals with PTSD and is thought to catalyze stress-related biobehavioral changes that might impact both brain structure and function in adulthood. The current study examined differences in brain morphology (brain volume, cortical thickness) and neuropsychological performance in individuals with PTSD characterized by low or high self-reported childhood maltreatment, compared with healthy comparison participants. Data were drawn from the INjury and TRaUmatic STress (INTRuST) Clinical Consortium imaging repository, which contains MRI and self-report data for individuals classified as PTSD positive (with and without a history of mild traumatic brain injury [mTBI]), individuals with mTBI only, and healthy comparison participants. The final sample included 36 individuals with PTSD without childhood maltreatment exposure (PTSD, n = 30 with mTBI), 31 individuals with PTSD and childhood maltreatment exposure (PTSD + M, n = 26 with mTBI), and 114 healthy comparison participants without history of childhood maltreatment exposure (HC). The PTSD + M and PTSD groups demonstrated cortical thinning in prefrontal and occipital regions, and poorer verbal memory and processing speed compared to the HC group. PTSD + M participants demonstrated cortical thinning in frontal and cingulate regions, and poorer executive functioning relative to the PTSD and HC groups. Thus, neurocognitive features varied between individuals with PTSD who did versus did not have exposure to childhood maltreatment, highlighting the need to assess developmental history of maltreatment when examining biomarkers in PTSD.

Indexed as

Adult Survivors of Child AbuseAdultBiomarkersCerebral CortexCognitive DysfunctionDatabases, FactualExecutive FunctionFemaleHumansMagnetic Resonance ImagingMaleMiddle AgedStress Disorders, Post-TraumaticYoung AdultBiomarkersChildhood maltreatmentCortical thicknessMorphologyMRIPTSD

Identifiers

PMID31809943
PMCPMC7568209

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.