Evidence map›Paper›PMID 31809738›Full record

ArticleCell stem cell2019

Hic1 Defines Quiescent Mesenchymal Progenitor Subpopulations with Distinct Functions and Fates in Skeletal Muscle Regeneration.

R Wilder Scott, Martin Arostegui, Ronen Schweitzer, Fabio M V Rossi, T Michael Underhill

Open access · bronzeAbstract read
In one paragraph

Article in Cell stem cell, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 126 papers.

0numbers the graph read from it
0cells of the map it votes in
126citing papers in PubMed
8.6field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

126 citing papers in PubMed, 223 citations in OpenAlex.

  1. DNA methylation alterations in muscle of critically ill patients.Journal of cachexia, sarcopenia and muscle · 2022
    Trial
  2. Article
  3. A who's who of cell types in skeletal muscle.Communications biology · 2026
    Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Myotendinous Junction development and repair.Journal of orthopaedic translation · 2026
    Review
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. Article
  16. Mapping the Tissue-of-Origins of Mesenchymal Stromal Cells in Injury Repair.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  17. Article
  18. Review
  19. Review
  20. Spatial Transcriptomics RevealsbioRxiv : the preprint server for biology · 2025
    Article

66 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

R Wilder ScottDepartment of Cellular and Physiological Sciences, 2222 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; School of Biomedical Engineering and the Biomedical Research Centre, 2222 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Martin ArosteguiDepartment of Cellular and Physiological Sciences, 2222 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
Ronen SchweitzerResearch Division, Shriners Hospital for Children, Portland, OR 97239, USA.
Fabio M V RossiDepartment of Medical Genetics, 2222 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; School of Biomedical Engineering and the Biomedical Research Centre, 2222 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada.
T Michael UnderhillDepartment of Cellular and Physiological Sciences, 2222 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada; School of Biomedical Engineering and the Biomedical Research Centre, 2222 Health Sciences Mall, University of British Columbia, Vancouver, BC, V6T 1Z3, Canada. Electronic address: tunderhi@brc.ubc.ca.
University of British Columbia · CAShriners Hospitals for Children - Portland · US

Funding

Targeting SS18-SSX biology in synovial sarcomagenesisU54CA231652 · NCI · UNIVERSITY OF UTAH · PI JONES, KEVIN BRUCE · 2018 to 2022
$12.0M
NCI NIH HHS U54 CA231652
6 · The paper itself

Abstract

Many adult tissues contain resident stem cells, such as the Pax7

Indexed as

AnimalsCell CycleCell DifferentiationCell ProliferationCells, CulturedFemaleFluorescent Antibody TechniqueKruppel-Like Transcription FactorsMaleMiceMuscle, SkeletalRegenerationSatellite Cells, Skeletal MuscleWound HealingHic1 protein, mouseKruppel-Like Transcription Factorslineage tracingmesenchymal progenitorsmyotendinous junctionpericytesquiescencescATAC-seqscRNA-seqskeletal muscletendontissue regeneration

Identifiers

PMID31809738
PMCPMC6941576
OpenAlexW2992810674

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.