ReviewBrain research2020
Reverse engineering human brain evolution using organoid models.
Review in Brain research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Developmental signaling reveals functionally enriched human-specific gene regulation in telencephalic progenitors.bioRxiv : the preprint server for biology · 2026Article
- A modular platform for automated organoid culture and longitudinal imaging.Scientific reports · 2026Article
- From microfluidics to nanodelivery: artificial intelligence reshapes neuropharmacology research strategies.Frontiers in pharmacology · 2026Review
- Interspecies Organoids Reveal Human-Specific Molecular Features of Dopaminergic Neuron Development and Vulnerability.bioRxiv : the preprint server for biology · 2025Article
- Fate plasticity of interneuron specification.iScience · 2025Article
- Implementation and validation of single-cell genomics experiments in neuroscience.Nature neuroscience · 2024Review
- SIMS: A deep-learning label transfer tool for single-cell RNA sequencing analysis.Cell genomics · 2024Article
- Modulation of neuronal activity in cortical organoids with bioelectronic delivery of ions and neurotransmitters.Cell reports methods · 2024Article
- Internet-Connected Cortical Organoids for Project-Based Stem Cell and Neuroscience Education.eNeuro · 2023Article
- Unraveling Neuronal Identities Using SIMS: A Deep Learning Label Transfer Tool for Single-Cell RNA Sequencing Analysis.bioRxiv : the preprint server for biology · 2023Article
- Human-specific genetics: new tools to explore the molecular and cellular basis of human evolution.Nature reviews. Genetics · 2023Review
- Internet-connected cortical organoids for project-based stem cell and neuroscience education.bioRxiv : the preprint server for biology · 2023Article
- Functional bioengineered models of the central nervous system.Nature reviews bioengineering · 2023Review
- Evaluation of advances in cortical development using model systems.Developmental neurobiology · 2022Review
- Physiological Electric Field: A Potential Construction Regulator of Human Brain Organoids.International journal of molecular sciences · 2022Review
- A Brain Region-Specific Expression Profile for Genes Within Large Introgression Deserts and Under Positive Selection inFrontiers in cell and developmental biology · 2022Article
- Genetic Diversity in Chimpanzee Transcriptomics Does Not Represent Wild Populations.Genome biology and evolution · 2021Article
- Picroscope: low-cost system for simultaneous longitudinal biological imaging.Communications biology · 2021Article
- Comparative analysis reveals distinctive epigenetic features of the human cerebellum.PLoS genetics · 2021Article
- A low-cost 3D printed microfluidic bioreactor and imaging chamber for live-organoid imaging.Biomicrofluidics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
Primate brains vary dramatically in size and organization, but the genetic and developmental basis for these differences has been difficult to study due to lack of experimental models. Pluripotent stem cells and brain organoids provide a potential opportunity for comparative and functional studies of evolutionary differences, particularly during the early stages of neurogenesis. However, many challenges remain, including isolating stem cell lines from additional great ape individuals and species to capture the breadth of ape genetic diversity, improving the reproducibility of organoid models to study evolved differences in cell composition and combining multiple brain regions to capture connectivity relationships. Here, we describe strategies for identifying evolved developmental differences between humans and non-human primates and for isolating the underlying cellular and genetic mechanisms using comparative analyses, chimeric organoid culture, and genome engineering. In particular, we focus on how organoid models could ultimately be applied beyond studies of progenitor cell evolution to decode the origin of recent changes in cellular organization, connectivity patterns, myelination, synaptic development, and physiology that have been implicated in human cognition.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.