Evidence map›Paper›PMID 31809667›Full record

ArticleThe Journal of asthma : official journal of the Association for the Care of Asthma2021

Cassandra C Brooks, Lisa J Martin, Valentina Pilipenko, Hua He, Grace K LeMasters, James E Lockey, David I Bernstein, Patrick H Ryan, Gurjit K Khurana Hershey, Jocelyn M Biagini Myers

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of asthma : official journal of the Association for the Care of Asthma, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.8field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 6 citations in OpenAlex.

  1. Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Review
  2. Second-hand smoke and NFE2L2 genotype interaction increases paediatric asthma risk and severity.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2021
    Article
  3. Impact of Air Pollution on Asthma Outcomes.International journal of environmental research and public health · 2020
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Cassandra C BrooksDivision of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Lisa J MartinDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Valentina Pilipenko
Hua HeDivision of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Grace K LeMastersDepartment of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.
James E LockeyDepartment of Environmental Health, University of Cincinnati, Cincinnati, OH, USA.
David I BernsteinDepartment of Internal Medicine, University of Cincinnati, Cincinnati, OH, USA.
Patrick H RyanDivision of Biostatistics and Epidemiology, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Gurjit K Khurana HersheyDivision of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Jocelyn M Biagini MyersDivision of Asthma Research, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Cincinnati Children's Hospital Medical Center · USUniversity of Cincinnati · US

Funding

REPRODUCTIVE AND DEVELOPMENTAL TOXICOLOGY RESEARCHP30ES006096 · NIEHS · UNIVERSITY OF CINCINNATI · PI PINNEY, SUSAN MENGEL · 1992 to 2022
$35.4M
Diesel, Allergens and Gene Interaction and Child AtopyR01ES011170 · NIEHS · UNIVERSITY OF CINCINNATI · PI LEMASTERS, GRACE · 2001 to 2009
$10.4M
Ruth L. Kirschstein National Research Service Award Short-Term Institutional ReseT35HL113229 · NHLBI · CINCINNATI CHILDRENS HOSP MED CTR · PI Raouf S. Amin, WILLIAM DAVID HARDIE · 2012 to 2026
$922k
NHLBI NIH HHS T35 HL113229NIEHS NIH HHS P30 ES006096NIEHS NIH HHS R01 ES011170
6 · The paper itself

Abstract

objectiveWe previously reported that children exposed to secondhand smoke (SHS) that carried variants in the NAT1 gene had over two-fold higher hair cotinine levels. Our objective was to determine if NAT1 polymorphisms confer increased risk for developing asthma in children exposed to SHS.

methodsWhite participants in the Cincinnati Childhood Allergy and Air Pollution Study (

resultsSignificant associations between 5

conclusionsVariation in the

Indexed as

AllelesArylamine N-AcetyltransferaseAsthmaChildChild, PreschoolCotinineEnvironmental ExposureFemaleGenotypeHairHumansInfantIsoenzymesMalePolymorphism, Single NucleotideSpirometryArylamine N-AcetyltransferaseCotinineIsoenzymesN-acetyltransferase 1Tobacco Smoke PollutionasthmachildrenNAT1secondhand smoke exposure

Identifiers

PMID31809667
PMCPMC7274907
OpenAlexW2994598295

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.