Evidence map›Paper›PMID 31809514›Full record

ArticlePloS one2019

Polyvinylalcohol-carbazate (PVAC) reduces red blood cell hemolysis.

Felix Sellberg, Fanny Fredriksson, Thomas Engstrand, Tim Melander Bowden, Bo Nilsson, Jaan Hong, Folke Knutson, David Berglund

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Felix SellbergDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.ORCID 0000-0002-9742-244X
Fanny FredrikssonDepartment of Women's and Children's Health, Section of Pediatric Surgery, Uppsala University, Uppsala, Sweden.
Thomas EngstrandDepartment of Surgical Sciences, Uppsala University, Uppsala, Sweden.
Tim Melander BowdenDepartment of Chemistry-Ångström Laboratory, Uppsala University, Uppsala, Sweden.
Bo NilssonDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Jaan HongDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Folke KnutsonDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
David BerglundDepartment of Immunology, Genetics and Pathology, Uppsala University, Uppsala, Sweden.
Uppsala University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND AND

objectivesThe objective of this study was to investigate whether a soluble polymer and aldehyde-scavenger, polyvinylalcohol-carbazate (PVAC), can inhibit hemolysis in the storage of red blood cells (RBC). STUDY DESIGN AND

methodsThe effect of PVAC was assessed over a wide range of concentrations, using absorption spectroscopy to evaluate the level of hemolysis. Moreover, osmotic stability and aldehyde-scavenging potential of RBC were assessed after storage in PVAC.

resultsAfter test tube storage for two weeks, red blood cell hemolysis was lower with PVAC compared to controls (mean difference 23%, 95% CI 16-29%, p < 0.001). A higher level of hemolysis led to a pronounced effect with PVAC. RBC stored in PVAC improved both the binding of free aldehydes (p <0.001) and the osmotic stability (p = 0.0036).

conclusionErythrocytes stored with PVAC showed less hemolysis, which might be explained by the ability of PVACs to stabilize the cell membrane and decrease oxidative injury.

Indexed as

AldehydesBlood PreservationErythrocytesHemolysisHumansHydrazinesOsmotic FragilityPolyvinyl AlcoholSolutionsAldehydescarbazic acidHydrazinesPolyvinyl AlcoholSolutions

Identifiers

PMID31809514
PMCPMC6897416
OpenAlexW2992026677

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.