ArticlePloS one2019
Influence of Debaryomyces hansenii on bacterial lactase gene diversity in intestinal mucosa of mice with antibiotic-associated diarrhea.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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19 citing papers in PubMed, 21 citations in OpenAlex.
- Therapeutic potential of Sishen Pill: modulating intestinal mucosal microbiota and barrier function in diarrhea-predominant irritable bowel syndrome with Spleen-Kidney Yang Deficiency.Bioscience of microbiota, food and health · 2026Article
- The effects of functional biscuits on intestinal mucosal microbiota composition, brain function, and antioxidant activity.Bioscience of microbiota, food and health · 2025Article
- One mechanism of Sishen Pill on diarrhea with kidney Yang deficiency syndrome: influencing metabolic function by intestinal microorganisms and enzyme activity mediates the gut-kidney axis.Frontiers in cellular and infection microbiology · 2025Article
- Association of intestinal mucosal barrier function with intestinal microbiota in Spleen-Kidney Yang Deficiency IBS-D mice.Frontiers in microbiology · 2025Article
- Diarrhea Caused by High-Fat and High-Protein Diet Was Associated With Intestinal Lactase-Producing Bacteria.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2023Article
- Microbial applications for sustainable space exploration beyond low Earth orbit.NPJ microgravity · 2023Review
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- Probiotic3 Biotech · 2023Article
- Lactase bacteria in intestinal mucosa are associated with diarrhea caused by high-fat and high-protein diet.BMC microbiology · 2022Article
- Sex hormones influence the intestinal microbiota composition in mice.Frontiers in microbiology · 2022Article
- Baohe pill decoction for diarrhea induced by high-fat and high-protein diet is associated with the structure of lactase-producing bacterial community.Frontiers in cellular and infection microbiology · 2022Article
- Diarrhea with deficiency kidney-yang syndrome caused by adenine combined withFrontiers in microbiology · 2022Article
- "Liver-gut" axis: A target of traditional Chinese medicine for the treatment of non-alcoholic fatty liver disease.Frontiers in endocrinology · 2022Review
- Pathogenicity of Salmonella During Schistosoma-Salmonella Co-infections and the Importance of the Gut Microbiota.Current microbiology · 2021Review
- Bioactive compounds and probiotics-a ray of hope in COVID-19 management.Food science and human wellness · 2021Review
- Effect of Gegenqinlian decoction on intestinal mucosal flora in mice with diarrhea induced by high temperature and humidity treatment.3 Biotech · 2021Article
- Recent advances in the application of probiotic yeasts, particularly Saccharomyces, as an adjuvant therapy in the management of cancer with focus on colorectal cancer.Molecular biology reports · 2021Review
- Intestinal mucosal bacterial diversity of antibiotic-associated diarrhea (AAD) mice treated with3 Biotech · 2020Article
- Microbiotal characteristics colonized in intestinal mucosa of mice with diarrhoea and repeated stress.3 Biotech · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimThe current study aimed to investigate the effects of Debaryomyces hansenii on the diversity of bacterial lactase gene in the intestinal mucosa of antibiotic-associated diarrhea (AAD) mice.
methodsEighteen mice were randomly divided into three groups (6 mice per group): healthy control group, diarrhea model group and D. hansenii treatment group. The antibiotic-associated diarrhea model was established by intragastric administration with a mixture of cephradine and gentamicin sulfate (23.33 mL·kg-1·d-1) twice a day for 5 days continuously. After establishing the AAD model, the mice in the D. hansenii treatment group were gavaged with D. hansenii for three days, while other groups were gavaged with distilled water. Then, the intestinal mucosa of all three groups was collected and DNA was extracted in an aseptic environment for the following analysis.
resultsThe difference in the richness and homogeneity of the bacterial lactase gene among all samples were inapparent, as the difference in the Chao1, ACE, Simpson and Shannon indices among the three groups were insignificant (P>0.05). NMDS analysis also showed that the distance of the samples among the three groups was unobvious. Furthermore, the bacterial lactase gene in the mucosa mainly originated from Actinobacteria, Firmicutes and Proteobacteria. Compared with the healthy control group, the abundance of lactase genes originating from Cupriavidus, Lysobacter, Citrobacter, Enterobacter and Pseudomonas was increased in the D. hansenii treatment group, while the lactase gene from Acidovorax and Stenotrophomonas decreased (p < 0.01 or p < 0.05) in the diarrhea model group and the D. hansenii treatment group.
conclusionD. hansenii was capable of improving the growth of some key lactase-producing bacteria like Deinococcus, Cupriavidus and Lysobacter for treating AAD.
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