ArticleObstetrics and gynecology2020
Persistent Opioid Use After Hysterectomy in the United States, 2005-2015.
Article in Obstetrics and gynecology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 2 of them syntheses that pooled it.
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Who cites it
12 citing papers in PubMed, 2 syntheses or guidelines pooled it, 32 citations in OpenAlex.
- Patient-related risk factors for new persistent opioid use after surgery among opioid-naïve individuals in the United States: a systematic review and meta-analysis.Pain medicine (Malden, Mass.) · 2026Pooled it
- Transversus abdominis plane (TAP) blocks for prevention of postoperative pain in women undergoing laparoscopic and robotic gynaecological surgery.The Cochrane database of systematic reviews · 2025Pooled it
- Risk factors for postoperative opioid prescription after benign hysterectomy.European journal of obstetrics & gynecology and reproductive biology: X · 2026Article
- Comparative analysis of postoperative outcomes following hysterectomy versus sacrocolpopexy: Insights from global federated health research network.European journal of obstetrics & gynecology and reproductive biology: X · 2025Article
- Long-Term Opioid Therapy and Risk of Opioid Overdose by Derived Clinical Indication in North Carolina, 2006-2018.Pharmacoepidemiology and drug safety · 2025Article
- Postoperative Opioid Administration and Prescription Practices Following Hysterectomy in Two Tertiary Care Centres: A Comparative Cohort Study between Canada and Austria.Journal of clinical medicine · 2024Article
- A prospective cohort study on perioperative percutaneous balloon compression for trigeminal neuralgia: safety and efficacy analysis.Neurosurgical review · 2024Article
- Age and postoperative opioid use in women undergoing pelvic organ prolapse surgery.Acta obstetricia et gynecologica Scandinavica · 2023Article
- Positive Association between Peri-Surgical Opioid Exposure and Post-Discharge Opioid-Related Outcomes.Healthcare (Basel, Switzerland) · 2022Article
- Optimizing post-operative opiate prescribing following gynecologic surgery.Gynecologic oncology reports · 2022Article
- Predictors of new persistent opioid use after benign hysterectomy in the United States.American journal of obstetrics and gynecology · 2022Article
- Perioperative opioid prescriptions associated with stress incontinence and pelvic organ prolapse surgery.American journal of obstetrics and gynecology · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo assess variables associated with opioid prescriptions filled perioperatively after hysterectomy and the risk of prolonged opioid use through 1 year after hysterectomy.
methodsIn this retrospective cohort study, we used the 2005-2015 IBM MarketScan databases to identify women aged at least 18 years who underwent hysterectomy. For opioid use, we identified filled prescriptions for opioid medications. We excluded women with prevalent opioid use, defined as an opioid prescription filled 180 to 30 days preoperatively or at least two prescriptions filled in the 30 days before surgery. We defined perioperative opioid use as any opioid prescription filled within 30 days before or 7 days after surgery. We used log-binomial regression to identify independent predictors of perioperative opioid prescription fill. To assess the risk of long-term opioid use, we estimated the proportion of women with ongoing monthly opioid prescriptions through 12 months after surgery and the proportion of women with any opioid prescription 3-6 months after surgery, mimicking published estimates.
resultsAmong 569,634 women who underwent hysterectomy during the study period, 176,537 (30.9%) were excluded owing to prevalent opioid use. We found that 331,322 (84.3%) women filled a perioperative opioid prescription, with median quantity of 30 pills (interquartile range 25-40), and that younger (adjusted risk ratio [adjRR]18-24 0.91) and older (adjRR65-74 0.84; adjRR75+ 0.70) patients were less likely to receive a perioperative prescription compared with women aged 45-54. The proportion of women with continuous monthly fills of opioids through 2, 3, 6, and 12 months after surgery was 1.40%, 0.34%, 0.06%, and 0.02%, respectively.
conclusionMost women who underwent hysterectomy in the United States from 2005 to 2015 filled a perioperative opioid prescription with a median quantity of 30 pills. The risk of prolonged opioid use through 6 months is quite low, at 0.06% or 1 in 1,547.
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