Evidence map›Paper›PMID 31809194›Full record

ArticleThe CRISPR journal2019

A Type IV-A CRISPR-Cas System in

Valerie M Crowley, Adam Catching, Hannah N Taylor, Adair L Borges, Josie Metcalf, Joseph Bondy-Denomy, Ryan N Jackson

Abstract read
In one paragraph

Article in The CRISPR journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 58 citations in OpenAlex.

  1. Review
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  7. Review
  8. The extended mobility of plasmids.Nucleic acids research · 2025
    Review
  9. Bacteriophages inMicrobial genomics · 2025
    Article
  10. Review
  11. Structure, function and evolution of the bacterial DinG-like proteins.Computational and structural biotechnology journal · 2025
    Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Valerie M CrowleyDepartment of Chemistry and Biochemistry, Utah State University, Logan, Utah.
Adam CatchingGraduate Group in Biophysics, University of California, San Francisco, San Francisco, California.
Hannah N TaylorDepartment of Chemistry and Biochemistry, Utah State University, Logan, Utah.
Adair L BorgesDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, California.
Josie MetcalfDepartment of Chemistry and Biochemistry, Utah State University, Logan, Utah.
Joseph Bondy-DenomyDepartment of Microbiology and Immunology, University of California, San Francisco, San Francisco, California.
Ryan N JacksonDepartment of Chemistry and Biochemistry, Utah State University, Logan, Utah.
Utah State University · USUniversity of California, San Francisco · US

Funding

STRUCTURAL BIOLOGY TRAINING PROGRAMT32GM008284 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KORTEMME, TANJA · 1988 to 2022
$10.1M
Microbial Pathogenesis and Host DefenseT32AI060537 · NIAID · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Joanne N. Engel · 2004 to 2026
$6.5M
Discovering New Roles for CRISPR-Cas in Bacterial PathogenesisDP5OD021344 · OD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BONDY-DENOMY, JOSEPH · 2015 to 2019
$2.1M
Uncovering the mechanism and role of a widespread anti-CRISPR-Cas9 proteinR01GM127489 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI BONDY-DENOMY, JOSEPH · 2018 to 2022
$1.7M
NIAID NIH HHS T32 AI060537NIGMS NIH HHS R01 GM127489NIGMS NIH HHS T32 GM008284NIH HHS DP5 OD021344
6 · The paper itself

Abstract

Bacteria and archaea use CRISPR-Cas adaptive immune systems to destroy complementary nucleic acids using RNAs derived from CRISPR loci. Here, we provide the first functional evidence for type IV CRISPR-Cas, demonstrating that the system from

Indexed as

BacteriaClustered Regularly Interspaced Short Palindromic RepeatsCRISPR-Cas SystemsPlasmidsPseudomonas aeruginosaRNA, Guide, CRISPR-Cas SystemsRNA InterferenceRNA, Guide, CRISPR-Cas Systems

Identifiers

PMID31809194
PMCPMC6919247
OpenAlexW2993668959

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.