Evidence map›Paper›PMID 31808949›Full record

ArticleMedical physics2020

MRIgRT head and neck anthropomorphic QA phantom: Design, development, reproducibility, and feasibility study.

A Steinmann, P Alvarez, H Lee, L Court, R Stafford, G Sawakuchi, Z Wen, C D Fuller, D Followill

Abstract read
In one paragraph

Article in Medical physics, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. On the MLC leaves alignment in the direction orthogonal to movement.Journal of applied clinical medical physics · 2021
    Article
  8. Review
  9. 3D dosimetric validation of ultrasound-guided radiotherapy with a dynamically deformable abdominal phantom.Physica medica : PM : an international journal devoted to the applications of physics to medicine and biology : official journal of the Italian Association of Biomedical Physics (AIFB) · 2021
    Article
  10. Article
  11. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

A SteinmannDepartment of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
P AlvarezDepartment of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
H LeeDepartment of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
L CourtDepartment of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
R StaffordDepartment of Imaging Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
G SawakuchiDepartment of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
Z WenDepartment of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
C D FullerDepartment of Radiation Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.
D FollowillDepartment of Radiation Physics, The University of Texas M. D. Anderson Cancer Center, Houston, TX, 77030, USA.

Funding

IROC: Enhancing local enrolling site radiological data capture capabilities for NCTN trialsU24CA180803 · NCI · AMERICAN COLLEGE OF RADIOLOGY · PI Thomas J. FitzGerald, MICHAEL V KNOPP · 2014 to 2026
$116.2M
Development of functional magnetic resonance imaging-guided adaptive radiotherapy for head and neck cancer patients using novel MR-Linac deviceR01DE028290 · NIDCR · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI CHRISTODOULEAS, JOHN PAUL, FULLER, CLIFTON DAVID · 2019 to 2023
$4.3M
imaging Radiation-Associated Dysphagia (iRAD)R01CA218148 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI FULLER, CLIFTON DAVID, HUTCHESON, KATHERINE ARNOLD · 2017 to 2019
$810k
Andrew Sabin Family FoundationNCI NIH HHS R01 CA218148NCI NIH HHS U24 CA180803NIDCR NIH HHS R01 DE028290Sabin Family Foundation FellowUnited States Department of Health and Human Services
6 · The paper itself

Abstract

purposeThe purpose of this paper was to design, manufacture, and evaluate a tissue equivalent, dual magnetic resonance/computed tomography (MR/CT) visible anthropomorphic head and neck (H&N) phantom. This phantom was specially designed as an end-to-end quality assurance (QA) tool for MR imaging guided radiotherapy (MRIgRT) systems participating in NCI-sponsored clinical trials.

methodThe MRIgRT H&N phantom was constructed using a water-fillable acrylic shell and a custom insert that mimics an organ at risk (OAR) and target structures. The insert consists of a primary and secondary planning target volume (PTV) manufactured of a synthetic Clear Ballistic gel, an acrylic OAR and surrounding tissue fabricated using melted Superflab. Radiochromic EBT3 film and thermoluminescent detectors (TLDs) were used to measure the dose distribution and absolute dose, respectively. The phantom was evaluated by conducting an end-to-end test that included: imaging on a GE Lightspeed CT simulator, planning on Monaco treatment planning software (TPS), verifying treatment setup with MR, and irradiating on Elekta's 1.5 T Unity MR linac system. The phantom was irradiated three times using the same plan to determine reproducibility. Three institutions, equipped with either ViewRay MRIdian

resultsThe MRIgRT H&N phantom on the Unity system resulted in reproducible TLD doses (SD < 1.5%). The measured TLD to calculated dose ratios for the Unity system ranged from 0.94 to 0.98. The Viewray dose result comparisons had a larger range (0.95-1.03) but these depended on the TPS dose calculations from each site. Using a 7%/4 mm gamma analysis, Viewray institutions had average axial and sagittal passing rates of 97.3% and 96.2% and the Unity system had average passing rates of 97.8% and 89.7%, respectively. All of the results were within the Imaging and Radiation Oncology Core in Houston (IROC-Houston) standard credentialing criteria of 7% on TLDs, and >85% of pixels passing gamma analysis using 7%/4 mm on films.

conclusionsAn MRIgRT H&N phantom that is tissue equivalent and visible on both CT and MR was developed. The results from initial reproducibility and feasibility testing of the MRIgRT H&N phantom using the tested MGIgRT systems suggests the phantom's potential utility as a credentialing tool for NCI-clinical trials.

Indexed as

Clinical Trials as TopicEquipment DesignFeasibility StudiesHeadHumansMagnetic Resonance ImagingNeckPhantoms, ImagingQuality ControlRadiotherapy, Image-GuidedTomography, X-Ray Computeddual modality QA phantomend-to-end QA testMRIgRTMR LinacsUnityViewRay

Identifiers

PMID31808949
PMCPMC7796776

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.