ArticleMolecular biology and evolution2020
The Laboratory Domestication of Zebrafish: From Diverse Populations to Inbred Substrains.
Article in Molecular biology and evolution, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.
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Who cites it
27 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Social Preference Tests in Zebrafish: A Systematic Review.Frontiers in veterinary science · 2020Pooled it
- Zebrafish relatives as models for functional comparative genetics and genomics.Nature reviews. Genetics · 2026Review
- Routine metabolic rate is not associated with boldness in zebrafish.Biology open · 2026Article
- Article
- CompletebioRxiv : the preprint server for biology · 2025Article
- Decision-making in shoaling: zebrafish integrate cues of familiarity and group size.Animal cognition · 2025Article
- Regulation of early gonocyte differentiation in zebrafish.Biochemical Society transactions · 2025Article
- Variability of morphology-performance relationships under acute exposure to different temperatures in 3 strains of zebrafish.Current zoology · 2025Article
- EthoCRED: a framework to guide reporting and evaluation of the relevance and reliability of behavioural ecotoxicity studies.Biological reviews of the Cambridge Philosophical Society · 2025Review
- Genomic consequences of intensive inbreeding in miniature inbred pigs.BMC genomics · 2025Article
- The hybrid history of zebrafish.G3 (Bethesda, Md.) · 2025Article
- Medaka (Oryzias latipes) initiate courtship and spawning late at night: Insights from field observations.PloS one · 2025Article
- Temperature-dependence of early development of zebrafish and the consequences for laboratory use and animal welfare.PloS one · 2025Article
- New approach to the development of tailor-made feed for fish larvae using Zebrafish Danio rerio as a model.PloS one · 2025Article
- Copy number variation and population-specific immune genes in the model vertebrate zebrafish.eLife · 2024Article
- Advancing nuclear transfer cloning in zebrafish (Danio rerio) into a translational pathway using interdisciplinary tools.PloS one · 2024Article
- Facial analytics based on a coordinate extrapolation system (zFACE) for morphometric phenotyping of developing zebrafish.Disease models & mechanisms · 2023Article
- Immune gene variation associated with chromosome-scale differences among individual zebrafish genomes.Scientific reports · 2023Article
- Environmentally-induced sex reversal in fish with chromosomal vs. polygenic sex determination.Environmental research · 2022Article
- Reduced physiological plasticity in a fish adapted to stable temperatures.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We know from human genetic studies that practically all aspects of biology are strongly influenced by the genetic background, as reflected in the advent of "personalized medicine." Yet, with few exceptions, this is not taken into account when using laboratory populations as animal model systems for research in these fields. Laboratory strains of zebrafish (Danio rerio) are widely used for research in vertebrate developmental biology, behavior, and physiology, for modeling diseases, and for testing pharmaceutic compounds in vivo. However, all of these strains are derived from artificial bottleneck events and therefore are likely to represent only a fraction of the genetic diversity present within the species. Here, we use restriction site-associated DNA sequencing to genetically characterize wild populations of zebrafish from India, Nepal, and Bangladesh, and to compare them to previously published data on four common laboratory strains. We measured nucleotide diversity, heterozygosity, and allele frequency spectra, and find that wild zebrafish are much more diverse than laboratory strains. Further, in wild zebrafish, there is a clear signal of GC-biased gene conversion that is missing in laboratory strains. We also find that zebrafish populations in Nepal and Bangladesh are most distinct from all other strains studied, making them an attractive subject for future studies of zebrafish population genetics and molecular ecology. Finally, isolates of the same strains kept in different laboratories show a pattern of ongoing differentiation into genetically distinct substrains. Together, our findings broaden the basis for future genetic, physiological, pharmaceutic, and evolutionary studies in Danio rerio.
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