ReviewHematology. American Society of Hematology. Education Program2019
Complications in pregnant women with sickle cell disease.
Review in Hematology. American Society of Hematology. Education Program, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 2 syntheses or guidelines pooled it, 88 citations in OpenAlex.
- Position statement on the management of pregnancy in sickle cell disease.The Australian & New Zealand journal of obstetrics & gynaecology · 2025Guideline
- Systematic review of outcome reporting in studies of SCD and pregnancy: marked heterogeneity hinders meaningful data synthesis.Blood advances · 2023Pooled it
- The acceptability and feasibility of a randomised controlled trial of serial prophylactic exchange blood transfusion versus usual care in pregnant women with sickle cell disease: a qualitative study.BMC pregnancy and childbirth · 2026Trial
- Prophylactic exchange transfusion in sickle cell disease pregnancy: a TAPS2 feasibility randomized controlled trial.Blood advances · 2024Trial
- Maternal Delivery Outcomes Associated With Acute Sickle Cell Crisis: A National Inpatient Analysis.Cureus · 2026Article
- "Heartbreak and Frustration'' experiences of healthcare providers caring for pregnant women with sickle cell disease in Uganda.PloS one · 2026Article
- Proactive management to improve outcomes of high-risk pregnancy in people with sickle cell disease.Hematology. American Society of Hematology. Education Program · 2025Review
- Postpartum Tubal Sterilization in Sickle Cell Disease in the 2012-2019 National Inpatient Sample.Journal of women's health (2002) · 2025Article
- Impact of sickle cell anaemia on reproductive health: a narrative review.Reproductive health · 2025Review
- Pregnancy-associated venous thromboembolism in sub-Saharan Africa: a case-control study and descriptive analysis of clinical phenotypes.Research and practice in thrombosis and haemostasis · 2025Article
- Characterizing pregnancy outcomes in a humanized mouse model of sickle cell disease.British journal of haematology · 2025Article
- Diagnostic Overshadowing and the Unseen Spectrum: A Narrative Review of Rare Complications in Sickle Cell Disease.Clinics and practice · 2025Review
- Article
- Thalassemias and Sickle Cell Diseases in Pregnancy: SITE Good Practice.Journal of clinical medicine · 2025Article
- Histomorphology of placentae of women with sickle cell disease during pregnancy - A case control study.PloS one · 2025Article
- Prophylactic vs therapeutic blood transfusions impact on pregnant sickle cell patients.Pakistan journal of medical sciences · 2025Article
- Sickle cell disease and increased adverse maternal and perinatal outcomes in different genotypes.Hematology, transfusion and cell therapy · 2024Article
- Assessing the Impact of Hematological Changes in Pregnancy on Maternal and Fetal Death: A Narrative Review.Cureus · 2024Review
- Ovarian Tissue Cryopreservation for Fertility Preservation in Patients with Hemoglobin Disorders: A Comprehensive Review.Journal of clinical medicine · 2024Review
- Management of diabetes mellitus patients with sickle cell anemia: Challenges and therapeutic approaches.Medicine · 2024Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pregnancy in women with sickle cell disease (SCD) is associated with increased maternal and fetal morbidity and mortality. Outcomes vary widely owing to methodological limitations of clinical studies, but overall, hypertensive disorders of pregnancy, venothromboembolism, poor fetal growth, and maternal and perinatal mortality are increased globally. Few therapeutic interventions have been explored other than prophylactic and selective transfusion therapy. Unfortunately, existing data are limited, and it remains unclear whether prophylactic use of chronic transfusions will improve pregnancy outcomes. Management of pregnant women with SCD is best accomplished with a multidisciplinary team that includes a sickle cell expert and an obstetrician familiar with high-risk pregnancies. Women with SCD should have individualized care plans that outline management of acute pain and guidelines for transfusion therapy. Neonates require close monitoring for neonatal abstinence syndrome and hemolytic disease of the newborn. Ideally all young women with SCD will have a "reproductive life plan" developed as a component of preconception counseling and health promotion. Research leading to improved pregnancy management focused on diminishing adverse maternal and neonatal outcomes is overdue. International collaborations should be considered to improve subject recruitment and foster timely completion of clinical trials. Additional therapeutic interventions outside of transfusion therapy should be explored.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.