ArticleJournal of cellular and molecular medicine2020
Association of suboptimal health status with intestinal microbiota in Chinese youths.
Article in Journal of cellular and molecular medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 31 citations in OpenAlex.
- Effects of a comprehensive management mode for overweight/obesity based on mobile internet technology and traditional Chinese medicine constitution theory: a randomized controlled trial.Frontiers in nutrition · 2026Trial
- The suboptimal health status questionnaire: Turkish validity and reliability study.Frontiers in public health · 2026Article
- The intestinal flora and nutritional status and immune function characteristics of obese colon cancer patients.BMC gastroenterology · 2024Article
- Evaluating the association between effort-reward imbalance and suboptimal health status among hospital nurses: a cross-sectional study.International journal of occupational medicine and environmental health · 2024Article
- Validity and reliability of the Persian version of the Suboptimal Health Status Questionnaire among university staff in Iran.Journal of global health · 2023Article
- Translation and cross-cultural validation of a precision health tool, the Suboptimal Health Status Questionnaire-25, in Korean.Journal of global health · 2022Article
- Glycomic biomarkers are instrumental for suboptimal health status management in the context of predictive, preventive, and personalized medicine.The EPMA journal · 2022Article
- The Interactions of Media Use, Obesity, and Suboptimal Health Status: A Nationwide Time-Trend Study in China.International journal of environmental research and public health · 2021Article
- All around suboptimal health - a joint position paper of the Suboptimal Health Study Consortium and European Association for Predictive, Preventive and Personalised Medicine.The EPMA journal · 2021Article
- Construct validity of the Suboptimal Health Status Questionnaire-25 in a Ghanaian population.Health and quality of life outcomes · 2021Article
- Blood transcriptome profiling as potential biomarkers of suboptimal health status: potential utility of novel biomarkers for predictive, preventive, and personalized medicine strategy.The EPMA journal · 2021Article
- Associated Factors of Suboptimal Health Status Among Adolescents in China: A Cross-Sectional Study.Journal of multidisciplinary healthcare · 2021Article
- Glycosylation Profiling as a Biomarker of Suboptimal Health Status for Chronic Disease Stratification.Advances in experimental medicine and biology · 2021Article
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- Association of suboptimal health status with intestinal microbiota in Chinese youths.Journal of cellular and molecular medicine · 2020Article
Corrections and comments
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Authors and funding
17 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Suboptimal health status (SHS), a physical state between health and disease, is a subclinical and reversible stage of chronic disease. Previous studies have shown alterations in the intestinal microbiota in patients with some chronic diseases. This study aimed to investigate the association between SHS and intestinal microbiota in a case-control study with 50 SHS individuals and 50 matched healthy controls. Intestinal microbiota was analysed by MiSeq 250PE. Alpha diversity of intestinal microbiota in SHS individuals was higher compared with that of healthy controls (Simpson index, W = 2238, P = .048). Beta diversity was different between SHS and healthy controls (P = .018). At the phylum level, the relative abundance of Verrucomicrobia was higher in the SHS group than that in the controls (W = 2201, P = .049). Compared with that of the control group, nine genera were significantly higher and five genera were lower in abundance in the SHS group (all P < .05). The intestinal microbiota, analysed by a random forest model, was able to distinguish individuals with SHS from the controls, with an area under the curve of 0.79 (95% confidence interval: 0.77-0.81). We demonstrated that the alteration of intestinal microbiota occurs with SHS, an early stage of disease, which might shed light on the importance of intestinal microbiota in the primary prevention of noncommunicable chronic diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.