ArticleClinical kidney journal2019
Inflammatory leucocyte infiltrates are associated with recovery in biopsy-proven acute interstitial nephritis: a 20-year registry-based case series.
Article in Clinical kidney journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed, 10 citations in OpenAlex.
- Usefulness of gallium-67 scintigraphy for evaluating the histopathological activity in interstitial nephritis.Clinical and experimental nephrology · 2023Article
- Clinical significance of kidney immune complex deposition in children with acute interstitial nephritis disease.Renal failure · 2023Article
- Urine interleukin-9 and tumor necrosis factor-α for prognosis of human acute interstitial nephritis.Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association · 2021Article
- Atypical presentation of allergic interstitial nephritis likely induced by ciprofloxacin.BMJ case reports · 2021Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
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Abstract
backgroundAcute interstitial nephritis (AIN) is a renal injury causing renal function deterioration and requiring renal replacement therapy (RRT) in a substantial number of cases. Therapy is based on withdrawal of suspicious causative drugs or the underlying diseases and/or steroid application if renal function is not restored after cessation of the underlying condition. Hard clinical evidence for augmenting steroid therapy is not available.
methodsWe reviewed the course and diagnosis for >20 years among all 1126 biopsied samples of our tertiary renal centre.
results49 (4.4%) were diagnosed with primary AIN, corresponding to an annual incidence of 1/100 000 population; 17 out of 49 biopsy-proven AIN patients required short-term or long-term (
conclusionsFollowing our basic finding of the importance of histopathological parameters of acuity associated with recovery, we argue for the inauguration of grading measures to characterize this issue quantitatively and make it usable for future controlled investigations. Finally, we provide a suggestion for a therapeutic algorithm in the management of AIN.
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