Evidence map›Paper›PMID 31808316›Full record

ArticleCancer medicine2020

An international multicenter retrospective analysis of patients with extranodal marginal zone lymphoma and histologically confirmed central nervous system and dural involvement.

Andrew J Sunderland, Raphael E Steiner, Musa Al Zahrani, Chelsea C Pinnix, Bouthaina Shbib Dabaja, Jillian R Gunther, Loretta J Nastoupil, Mats Jerkeman, David Joske, Gavin Cull and 3 more

Abstract readMulticenter Study
In one paragraph

Article in Cancer medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Rare central nervous system lymphomas.British journal of haematology · 2022
    Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Andrew J SunderlandDepartment of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.ORCID 0000-0002-0541-5585
Raphael E SteinerDepartment of Lymphoma/Myeloma, MD Anderson Cancer Center, Houston, TX, USA.ORCID 0000-0003-3717-3629
Musa Al ZahraniUniversity of British Columbia and BC Cancer Centre for Lymphoid Cancer, Vancouver, British Columbia, Canada.
Chelsea C PinnixDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Bouthaina Shbib DabajaDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Jillian R GuntherDepartment of Radiation Oncology, MD Anderson Cancer Center, Houston, TX, USA.
Loretta J NastoupilDepartment of Lymphoma/Myeloma, MD Anderson Cancer Center, Houston, TX, USA.
Mats JerkemanSkånes University Hospital, Lund University, Lund, Sweden.
David JoskeDepartment of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Gavin CullDepartment of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.
Tarec El-GalalyDepartment of Hematology, Aalborg University Hospital, Aalborg, Denmark.
Diego VillaUniversity of British Columbia and BC Cancer Centre for Lymphoid Cancer, Vancouver, British Columbia, Canada.
Chan Yoon CheahDepartment of Haematology, Sir Charles Gairdner Hospital, Nedlands, WA, Australia.ORCID 0000-0001-7988-1565

Funding

Tumor Evolution and Metastasis ProgramP30CA016672 · NCI · UNIVERSITY OF TX MD ANDERSON CAN CTR · PI Kathrin Milbury · 1985 to 2026
$290.8M
NCI NIH HHS P30 CA016672
6 · The paper itself

Abstract

Marginal zone lymphoma of the central nervous system (CNS MZL) is rare. The clinical features, treatment, and prognosis are not well characterized. We performed a multicenter retrospective study of CNS MZL. Twenty-six patients were identified: half with primary and half with secondary CNS involvement. The median age was 59 years (range 26-78), 62% female and 79% with ECOG performance status ≤ 1. The most common disease site was the dura (50%). Treatment was determined by the treating physician and varied substantially. After a median follow up of 1.9 years, the estimated 2-year progression-free (PFS) and overall survival (OS) rates were 59% and 80%, respectively. Secondary CNS MZL was associated with 2-year OS of 58%. CNS MZL is rare, but relative to other forms of CNS lymphoma, outcomes appear favorable, particularly among the subset of patients with dural presentation and primary CNS presentation.

Indexed as

AdultAgedCentral Nervous System NeoplasmsCombined Modality TherapyDura MaterFemaleFollow-Up StudiesHumansLymphoma, B-Cell, Marginal ZoneMaleMiddle AgedPrognosisRetrospective StudiesSurvival RateCNS lymphomamarginal zone lymphoma

Identifiers

PMID31808316
PMCPMC6970027

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.