ArticleThoracic cancer2020
Is there any correlation between spectral CT imaging parameters and PD-L1 expression of lung adenocarcinoma?
Article in Thoracic cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 8 citations in OpenAlex.
- Quantitative spectral parameters of photon-counting detector CT for noninvasive prediction of PD-L1 expression in non-small cell lung cancer.BMC medical imaging · 2026Article
- Machine learning-driven imaging data for early prediction of lung toxicity in breast cancer radiotherapy.Scientific reports · 2025Article
- Review of the application of dual-energy CT combined with radiomics in the diagnosis and analysis of lung cancer.Journal of applied clinical medical physics · 2025Review
- Identification of PD-L1 Expression in Resectable NSCLC using Interpretable Machine Learning Model Based on Spectral CTCurrent medical imaging · 2025Article
- A prediction model based on dual-layer spectral detector computed tomography for distinguishing nonluminal from luminal invasive breast cancer.Quantitative imaging in medicine and surgery · 2024Article
- Predictive value of spectral dual-detector computed tomography forQuantitative imaging in medicine and surgery · 2024Article
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Authors and funding
6 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundThe aim of this study was to explore whether spectral computed tomography (CT) imaging parameters are associated with PD-L1 expression of lung adenocarcinoma.
methodsSpectral CT imaging parameters (iodine concentrations [IC] of lesion in arterial phase [ICLa] and venous phase [ICLv], normalized IC [NICa/NICv]-normalized to the IC in the aorta, slope of the spectral HU curve [λHUa/λHUv] and enhanced monochromatic CT number [CT40keVa/v, CT70keVa/v] on 40 and 70 keV images) were analyzed in 34 prospectively enrolled lung adenocarcinoma patients with common molecular pathological markers including PD-L1 expression detected with immunohistochemistry. Patients were divided into two groups: positive PD-L1 expression and negative PD-L1 expression groups. Two-sample Mann-Whitney U test was used to test the difference of spectral CT imaging parameters between the two groups.
resultsThe CT40keVa (127.03 ± 37.92 vs. -54.69 ± 262.04), CT40keVv (124.39 ± 34.71 vs. -45.73 ± 238.97), CT70keVa (49.56 ± 11.76 vs. -136.51 ± 237.08) and CT70keVv (46.13 ± 15.81 vs. -133.10 ± 230.72) parameters in the positive PD-L1 expression group of lung adenocarcinoma were significantly higher than the negative PD-L1 expression group (all P < 0.05). There was no difference detected in IC, NIC and λHU of the arterial and venous phases between both groups (all P > 0.05).
conclusionCT40keVa, CT40keVv, CT70keVa and CT70keVv were increased in positive PD-L1 expression. These parameters may be used to distinguish the PD-L1 expression state of lung adenocarcinoma.
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