ReviewAngewandte Chemie (International ed. in English)2020
A Case for Bond-Network Analysis in the Synthesis of Bridged Polycyclic Complex Molecules: Hetidine and Hetisine Diterpenoid Alkaloids.
Review in Angewandte Chemie (International ed. in English), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Total synthesis of natural products based on hydrogenation of aromatic rings.Beilstein journal of organic chemistry · 2026Review
- Total Synthesis of Aconicarmisulfonine A, a Sulfonated Diterpene Alkaloid.Journal of the American Chemical Society · 2025Article
- Total Synthesis of (-)-Neocucurbol C Enabled by Pattern Recognition and MHAT Cyclization.Journal of the American Chemical Society · 2025Article
- Azine Dearomatization in Natural Product Total Synthesis.Chemistry (Weinheim an der Bergstrasse, Germany) · 2025Review
- Molecular Complexity-Inspired Synthetic Strategies toward the Calyciphylline A-TypeJournal of the American Chemical Society · 2024Article
- Navigating Excess Complexity: Total Synthesis of Daphenylline.Journal of the American Chemical Society · 2024Article
- Natural Product Synthesis: The Endless Quest for Unreachable Perfection.ACS organic & inorganic Au · 2023Review
- Strategic application of C-H oxidation in natural product total synthesis.Nature reviews. Chemistry · 2023Review
- Unified Total Syntheses of Benzenoid Cephalotane-Type Norditerpenoids: Cephanolides and Ceforalides.Journal of the American Chemical Society · 2022Article
- Total synthesis of nine longiborneol sesquiterpenoids using a functionalized camphor strategy.Nature chemistry · 2022Article
- Retrosynthetic strategies and their impact on synthesis of arcutane natural products.Chemical science · 2020Review
- A Case for Bond-Network Analysis in the Synthesis of Bridged Polycyclic Complex Molecules: Hetidine and Hetisine Diterpenoid Alkaloids.Angewandte Chemie (International ed. in English) · 2020Review
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Authors and funding
3 authors.
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Abstract
A key challenge in the synthesis of diterpenoid alkaloids lies in identifying strategies that rapidly construct their multiply bridged polycyclic skeletons. Existing approaches to these structurally intricate secondary metabolites are discussed in the context of a "bond-network analysis" of molecular frameworks, which was originally devised by Corey some 40 years ago. The retrosynthesis plans that emerge from a topological analysis of the highly bridged frameworks of the diterpenoid alkaloids are discussed in the context of eight recent syntheses of hetidine and hetisine natural products and their derivatives. This Minireview highlights the extent to which network analyses of the type described here sufficed for designing synthesis plans, as well as areas where they had to be amalgamated with functional group oriented synthetic planning considerations.
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