Evidence map›Paper›PMID 31807987›Full record

Trial reportSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2020

Safety and feasibility of inspiratory muscle training for hospitalized patients undergoing hematopoietic stem cell transplantation: a randomized controlled study.

Leonardo Barbosa de Almeida, Patrícia Fernandes Trevizan, Mateus Camaroti Laterza, Abrahão Elias Hallack Neto, Ana Carolina Amaral de São José Perrone, Daniel Godoy Martinez

2 registry-linked trialsAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
0.8field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03373526 naunknown statusnot on this map

Effects of Aerobic Training and Inspiratory Muscle Training in Patients During Hematopoietic Stem Cell Transplantation

TypeinterventionalSponsorDaniel Godoy MartinezRan2017 to 2019Enrolled50ConditionsLymphoma, Myeloma, Leukemia, Aplastic AnemiaArmsInspiratory Muscle Training, Aerobic Training
NCT05710432 narecruitingnot on this mapstarted 2023, after this paper: background citation

Muscle Recruitment During Neck Flexion and Inspiratory Muscle Training in Difficult and Prolonged Weaning Patients: a Physiological Study - The FLEX Study

TypeinterventionalSponsorUnity Health TorontoRan2023 to 2025Enrolled10ConditionsMechanical Ventilator Weaning, Respiratory Muscle TrainingArmsQuasi-Isometric Neck Flexion, Inspiratory Muscle Training
3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Review
  4. Review
  5. Concerns and considerations in a hematopoietic stem cell transplant study with pulmonary rehabilitation and inspiratory muscle training.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Article
  6. Assessment of rehabilitation practices during hematopoietic stem cell transplantation in the United States: a survey.Rehabilitation oncology (American Physical Therapy Association. Oncology Section) · 2024
    Article
  7. Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Leonardo Barbosa de AlmeidaFederal University of Juiz de Fora, Cardiovascular Research Unit and Exercise Physiology, José Lourenço Kelmer, s/n, Martelos, Juiz de Fora, 36036-900, Brazil. almeidalb@hotmail.com.ORCID http://orcid.org/0000-0002-3840-9042
Patrícia Fernandes TrevizanFederal University of Juiz de Fora, Cardiovascular Research Unit and Exercise Physiology, José Lourenço Kelmer, s/n, Martelos, Juiz de Fora, 36036-900, Brazil.
Mateus Camaroti LaterzaFederal University of Juiz de Fora, Cardiovascular Research Unit and Exercise Physiology, José Lourenço Kelmer, s/n, Martelos, Juiz de Fora, 36036-900, Brazil.
Abrahão Elias Hallack NetoDepartment of Hematology, Hemotherapy and Bone Marrow Transplantation, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Ana Carolina Amaral de São José PerroneDepartment of Hematology, Hemotherapy and Bone Marrow Transplantation, Federal University of Juiz de Fora, Juiz de Fora, Brazil.
Daniel Godoy MartinezFederal University of Juiz de Fora, Cardiovascular Research Unit and Exercise Physiology, José Lourenço Kelmer, s/n, Martelos, Juiz de Fora, 36036-900, Brazil.
Universidade Federal de Juiz de Fora · BR

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 425702/2018-9Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Apoio ao Ensino, Pesquisa e Assistência do Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto da Universidade de São Paulo 8443327/2019
6 · The paper itself

Abstract

purposePatients undergoing hematopoietic stem cell transplantation (HSCT) usually experienced respiratory muscle weakness. Inspiratory muscle training (IMT) at HSCT has not been studied yet. Thus, it is important to evaluate the safety, feasibility, and preliminary effectiveness of IMT for hospitalized patients undergoing HSCT with an unstable and acute clinical condition.

methodsThis is a randomized controlled feasibility study. Thirty-one hospitalized patients undergoing HSCT were randomized to the conventional physical rehabilitation (CON) or to the IMT group (conventional physical rehabilitation + IMT). IMT was carried out at 40% of maximal inspiratory pressure (MIP), 5 sessions weekly, 10-20 min/session. Primary outcomes were safety and feasibility (recruitment, adherence, and attrition rates) of IMT. Secondary outcomes were respiratory strength, respiratory rate, oxygen saturation, and frequency of patients with oxygen desaturation, bleeding, dyspnea, and acute pulmonary edema.

resultsPatients were allocated to the IMT (N = 15; 43.6 years) or to the CON group (N = 16; 46.6 years). The recruitment rate was 100%, the adherence rate was 91%, and attrition was 13% to IMT. Two events were observed in 126 IMT sessions (1.5%). MIP increased in the IMT group (P < 0.01). No differences were observed in respiratory rate and oxygen saturation between groups. Trends to negative outcomes were observed in the CON in comparison to IMT group for a need of oxygen therapy (18% vs. 6%), bleeding (12% vs. 6%), dyspnea (25% vs. 13%), and acute pulmonary edema (6% vs. 0%).

conclusionsIMT is safe, feasible, and improves the inspiratory muscle strength in hospitalized patients undergoing HSCT.

trial registrationClinical trial registration: NCT03373526.

Indexed as

AdultBreathing ExercisesDyspneaFeasibility StudiesFemaleHematopoietic Stem Cell TransplantationHumansMaleMiddle AgedMuscle StrengthMuscle WeaknessPhysical Therapy ModalitiesProspective StudiesRespiratory MechanicsRespiratory MusclesBone marrow transplantationBreathing exercisesHematopoietic stem cell transplantationRehabilitation

Identifiers

PMID31807987
OpenAlexW2993650520

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.