Evidence map›Paper›PMID 31807915›Full record

ArticleJournal of neurology2020

Serial position effects rapidly distinguish Alzheimer's from frontotemporal dementia.

Nadine Kloth, Jolene Lemke, Heinz Wiendl, Sven G Meuth, Thomas Duning, Andreas Johnen

Abstract read
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Article in Journal of neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
  5. Article
  6. Delayed primacy recall performance predictsAlzheimer's & dementia (Amsterdam, Netherlands)
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Nadine KlothDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, Albert-Schweitzer-Campus, Building A1, 48149, Münster, Germany. nadine.kloth@ukmuenster.de.ORCID http://orcid.org/0000-0003-1473-303X
Jolene LemkeDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, Albert-Schweitzer-Campus, Building A1, 48149, Münster, Germany.
Heinz WiendlDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, Albert-Schweitzer-Campus, Building A1, 48149, Münster, Germany.
Sven G MeuthDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, Albert-Schweitzer-Campus, Building A1, 48149, Münster, Germany.
Thomas DuningDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, Albert-Schweitzer-Campus, Building A1, 48149, Münster, Germany.
Andreas JohnenDepartment of Neurology with Institute of Translational Neurology, University Hospital Muenster, Albert-Schweitzer-Campus, Building A1, 48149, Münster, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA significant proportion of patients with behavioural variant frontotemporal dementia (bvFTD) show memory impairments similar to patients with Alzheimer's disease (AD), making them prone to misdiagnosis in early disease stages. Our objective was to establish a rapid and efficient memory measure that enhances discrimination between patients with dementia due to Alzheimer's disease and amnestic presentations of behavioural variant frontotemporal dementia.

methodWord list learning data of patients with diagnoses of AD and both amnestic and non-amnestic presentations of bvFTD were analysed. The overall recall rate and the relative contributions of the first two (primacy items) and last two words (recency items) to recall performance were compared between groups.

resultsOverall recall rate was indistinguishable between patients with AD and amnestic bvFTD. However, AD patients' recall was mostly driven by recency items, whereas amnestic bvFTD patients' performance was mostly driven by primacy items.

conclusionWe conclude that obtaining a simple recency dominance index from a single, 15-item word list memory trial can help discriminate patients with AD from patients with bvFTD, even if they present with similarly severe memory impairment.

Indexed as

Memory and Learning TestsAgedAlzheimer DiseaseAmnesiaDiagnosis, DifferentialFemaleFrontotemporal DementiaHumansLearningMaleMental RecallMiddle AgedSeverity of Illness IndexAlzheimer’s diseaseBehavioural variant frontotemporal dementiaDifferential diagnosisEpisodic memorySerial position effectsWord list

Identifiers

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.