Evidence map›Paper›PMID 31807906›Full record

ReviewIntensive care medicine experimental2019

Methane and Inflammation - A Review (Fight Fire with Fire).

Marietta Zita Poles, László Juhász, Mihály Boros

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Intensive care medicine experimental, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  4. Review
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
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  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Marietta Zita PolesInstitute of Surgical Research, University of Szeged, Pulz u. 1., Szeged, H-6724, Hungary.
László JuhászInstitute of Surgical Research, University of Szeged, Pulz u. 1., Szeged, H-6724, Hungary.
Mihály BorosInstitute of Surgical Research, University of Szeged, Pulz u. 1., Szeged, H-6724, Hungary. boros.mihaly@med.u-szeged.hu.ORCID http://orcid.org/0000-0003-1410-1999

Funding

Emberi Eroforrások Minisztériuma 20391-3/2018/FEKUSTRATHungarian Scientific Research Fund NKFI K120232
6 · The paper itself

Abstract

Mammalian methanogenesis is regarded as an indicator of carbohydrate fermentation by anaerobic gastrointestinal flora. Once generated by microbes or released by a non-bacterial process, methane is generally considered to be biologically inactive. However, recent studies have provided evidence for methane bioactivity in various in vivo settings. The administration of methane either in gas form or solutions has been shown to have anti-inflammatory and neuroprotective effects in an array of experimental conditions, such as ischemia/reperfusion, endotoxemia and sepsis. It has also been demonstrated that exogenous methane influences the key regulatory mechanisms and cellular signalling pathways involved in oxidative and nitrosative stress responses. This review offers an insight into the latest findings on the multi-faceted organ protective activity of exogenous methane treatments with special emphasis on its versatile effects demonstrated in sepsis models.

Indexed as

BioactivityExogenous methaneIschemia/reperfusionMethanogenesisSepsis

Identifiers

PMID31807906
PMCPMC6895343

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.