ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2020
Intracranial pressure in the American Alligator (Alligator mississippiensis): reptilian meninges and orthostatic gradients.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed, 11 citations in OpenAlex.
- Anatomy of spinal CSF loss in the American alligator (Alligator mississippiensis).Journal of anatomy · 2025Article
- Constitutive Innate Immunity and Systemic Responses to Infection of the American Alligator (Animals : an open access journal from MDPI · 2024Article
- The presence of a foramen of Luschka in the American alligator (Alligator mississippiensis) and the continuity of the intraventricular and subdural spaces.Journal of anatomy · 2024Article
- Stuck on you: Meninges cellular crosstalk in development.Current opinion in neurobiology · 2023Review
- Dynamic asymmetry in cerebrospinal fluid pressure: An indicator of regional differences in compliance.Surgical neurology international · 2023Article
- The Influence of Movement on the Cerebrospinal Fluid Pressure of the American Alligator (Biology · 2022Article
- Treadmill locomotion in the American alligator (Alligator mississippiensis) produces dynamic changes in intracranial cerebrospinal fluid pressure.Scientific reports · 2022Article
- Article
- Variations in the cerebrospinal fluid dynamics of the American alligator (Alligator mississippiensis).Fluids and barriers of the CNS · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The cranial meninges of reptiles differ from the more widely studied mammalian pattern in that the intraventricular and subarachnoid spaces are, at least partially, isolated. This study was undertaken to investigate the bulk flow of cerebrospinal fluid, and the resulting changes in intracranial pressure, in a common reptilian species. Intracranial pressure was measured using ocular ultrasonography and by surgically implanting pressure cannulae into the cranial subarachnoid space. The system was then challenged by: rotating the animal to create orthostatic gradients, perturbation of the vascular system, administration of epinephrine, and cephalic cutaneous heating. Pressure changes determined from the implanted catheters and through quantification of the optic nerve sheath were highly correlated and showed a significant linear relationship with orthostatic gradients. The catheter pressure responses were phasic, with an initial rapid response followed by a much slower response; each phase accounted for roughly half of the total pressure change. No significant relationship was found between intracranial pressure and either heart rate or blood flow. The focal application of heat and the administration of epinephrine both increased intracranial pressure, the latter influence being particularly pronounced.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.