Evidence map›Paper›PMID 31807294›Full record

ArticleClinical kidney journal2019

Oxalate nephropathy is a major cause of kidney injury in surgically treated pancreatic adenocarcinoma patients.

Geoffroy Desbuissons, Hassan Izzedine, Armelle Bardier, Olivier Dubreuil, Jean Christophe Vaillant, Vincent Frochot, Lucile Mercadal

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical kidney journal, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 98% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Geoffroy DesbuissonsNephrology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
Hassan IzzedineNephrology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
Armelle BardierPathology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
Olivier DubreuilOncology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
Jean Christophe VaillantDepartment of Hepato Pancreato Biliary Surgery, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
Vincent FrochotPhysiology Unit, Tenon University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
Lucile MercadalNephrology Department, Pitié-Salpêtrière University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France.
Pitié-Salpêtrière Hospital · FRGénérale de Santé · FRSorbonne Université · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundDespite new therapeutics, the prognosis for pancreatic cancer remains poor. Pancreatic surgery is a therapeutic option in non-metastatic forms. The consequences for renal function are poorly described.

methodsPatients who underwent surgery for pancreatic cancer between 1 January 2010 and 1 January 2017 and who experienced kidney biopsy in the Pitié-Salpêtrière Hospital were analysed.

resultsTwo hundred and ninety-four patients had pancreatic surgery during the period of analysis and five of them had a kidney biopsy (mean ± SD 20 months ±13.6 months after surgery) during the post-operative follow-up. Among these patients, three exhibited oxalate nephropathy (ON), indicating that the prevalence of ON in patients with pancreatectomy is at least 1%. ON may be insidious, with chronic renal failure without urinary abnormalities. All patients had a high oxalate-to-creatinine ratio in urine sample. Renal function improved after specific management of ON in two patients. Pancreaticoduodenectomy may represent a higher risk of ON than left pancreatectomy.

conclusionAlthough rare and underestimated, ON appears to be a real risk after pancreatic resection. Early detection may preserve renal function.

Indexed as

chronic kidney diseaseoxalate nephropathypancreatectomypancreatic adenocarcinomapancreatic exocrine insufficiency

Identifiers

PMID31807294
PMCPMC6885689
OpenAlexW2916915063

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.