ReviewTranslational neurodegeneration2019
Oscillation-specific nodal alterations in early to middle stages Parkinson's disease.
Review in Translational neurodegeneration, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 20 citations in OpenAlex.
- Individualized cortico-basal ganglia-thalamo-cortical circuit dysfunction links striatal dopaminergic loss to motor symptom severity in Parkinson's disease.NPJ Parkinson's disease · 2026Article
- Energetic implications of fMRI-based nodal complex network metrics: a complex picture unfolds across diverse brain states.bioRxiv : the preprint server for biology · 2026Article
- Hot Topics and Frontiers of Resting-State fMRI in Parkinson's Disease: Research Trends and Paradigm Shifts From a Bibliometric Perspective.Parkinson's disease · 2025Review
- Frequency-dependent changes in the amplitude of low-frequency fluctuations in post stroke apathy: a resting-state fMRI study.Frontiers in psychiatry · 2025Article
- Brain network centrality and connectivity are associated with clinical subtypes and disease progression in Parkinson's disease.Brain imaging and behavior · 2024Article
- Frequency specific alterations of the degree centrality in patients with acute basal ganglia ischemic stroke: a resting-state fMRI study.Brain imaging and behavior · 2024Article
- Oscillation-Specific Nodal Differences in Parkinson's Disease Patients with Anxiety.Journal of Parkinson's disease · 2024Article
- The decoupling between hemodynamic parameters and neural activity implies a complex origin of spontaneous brain oscillations.Frontiers in computational neuroscience · 2023Article
- A multiple-tissue-specific magnetic resonance imaging model for diagnosing Parkinson's disease: a brain radiomics study.Neural regeneration research · 2022Article
- Resting-State Functional Network Topology Alterations of the Occipital Lobe Associated With Attention Impairment in Isolated Rapid Eye Movement Behavior Disorder.Frontiers in aging neuroscience · 2022Article
- Alterations of Regional Homogeneity in the Mild and Moderate Stages of Parkinson's Disease.Frontiers in aging neuroscience · 2021Article
- Abnormal Brain Connectivity in Carpal Tunnel Syndrome Assessed by Graph Theory.Journal of pain research · 2021Article
- Altered Brain Functional Network in Parkinson Disease With Rapid Eye Movement Sleep Behavior Disorder.Frontiers in neurology · 2020Article
Corrections and comments
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Authors and funding
15 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent oscillations of brain networks could carry different dimensions of brain integration. We aimed to investigate oscillation-specific nodal alterations in patients with Parkinson's disease (PD) across early stage to middle stage by using graph theory-based analysis.
methodsEighty-eight PD patients including 39 PD patients in the early stage (EPD) and 49 patients in the middle stage (MPD) and 36 controls were recruited in the present study. Graph theory-based network analyses from three oscillation frequencies (slow-5: 0.01-0.027 Hz; slow-4: 0.027-0.073 Hz; slow-3: 0.073-0.198 Hz) were analyzed. Nodal metrics (e.g. nodal degree centrality, betweenness centrality and nodal efficiency) were calculated.
resultsOur results showed that (1) a divergent effect of oscillation frequencies on nodal metrics, especially on nodal degree centrality and nodal efficiency, that the anteroventral neocortex and subcortex had high nodal metrics within low oscillation frequencies while the posterolateral neocortex had high values within the relative high oscillation frequency was observed, which visually showed that network was perturbed in PD; (2) PD patients in early stage relatively preserved nodal properties while MPD patients showed widespread abnormalities, which was consistently detected within all three oscillation frequencies; (3) the involvement of basal ganglia could be specifically observed within slow-5 oscillation frequency in MPD patients; (4) logistic regression and receiver operating characteristic curve analyses demonstrated that some of those oscillation-specific nodal alterations had the ability to well discriminate PD patients from controls or MPD from EPD patients at the individual level; (5) occipital disruption within high frequency (slow-3) made a significant influence on motor impairment which was dominated by akinesia and rigidity.
conclusionsCoupling various oscillations could provide potentially useful information for large-scale network and progressive oscillation-specific nodal alterations were observed in PD patients across early to middle stages.
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