Evidence map›Paper›PMID 31807283›Full record

ReviewF1000Research2019

Distinct roles of

Scott J Myers, Hongjie Yuan, Jing-Qiong Kang, Francis Chee Kuan Tan, Stephen F Traynelis, Chian-Ming Low

Open access · goldAbstract readReview
In one paragraph

Review in F1000Research, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 147 citations in OpenAlex.

  1. Article
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  5. Review
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  7. BDCD: a comprehensive Brain Disease Cell-cell communication Database.Database : the journal of biological databases and curation · 2026
    Article
  8. Article
  9. Review
  10. Article
  11. Joint analysis ofNAR genomics and bioinformatics · 2025
    Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Scott J MyersCenter for Functional Evaluation of Rare Variants (CFERV), Emory University, Atlanta, GA, USA.ORCID 0000-0002-1154-4842
Hongjie YuanCenter for Functional Evaluation of Rare Variants (CFERV), Emory University, Atlanta, GA, USA.
Jing-Qiong KangDepartment of Neurology, Vanderbilt Brain Institute, Vanderbilt Kennedy Center of Human Development, Vanderbilt University, Nashville, TN, USA.
Francis Chee Kuan TanDepartment of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-5272-9990
Stephen F TraynelisCenter for Functional Evaluation of Rare Variants (CFERV), Emory University, Atlanta, GA, USA.
Chian-Ming LowDepartment of Anaesthesia, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore.ORCID 0000-0002-1154-4842
Emory University · USNational University of Singapore · SGVanderbilt University · US

Funding

Glutamate receptors and human neurological diseaseR35NS111619 · NINDS · EMORY UNIVERSITY · PI Stephen F Traynelis · 2019 to 2026
$6.6M
Control of Glutamate Receptor FunctionR01NS036654 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 1998 to 2018
$3.7M
NMDAR Mutations & Neurodevelopmental Disorder: from Mechanism to Targeted TherapyR01HD082373 · NICHD · EMORY UNIVERSITY · PI YUAN, HONGJIE · 2015 to 2025
$3.3M
Control of glutamate receptor functionR37NS036654 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 2007 to 2013
$2.4M
Functional effects of ion channel mutations found via exome sequencingR24NS092989 · NINDS · EMORY UNIVERSITY · PI TRAYNELIS, STEPHEN F · 2016 to 2019
$1.1M
NICHD NIH HHS R01 HD082373NINDS NIH HHS R01 NS036654NINDS NIH HHS R24 NS092989NINDS NIH HHS R35 NS111619NINDS NIH HHS R37 NS036654
6 · The paper itself

Abstract

Rapid advances in sequencing technology have led to an explosive increase in the number of genetic variants identified in patients with neurological disease and have also enabled the assembly of a robust database of variants in healthy individuals. A surprising number of variants in the

Indexed as

EpilepsyNeurodevelopmental DisordersReceptors, N-Methyl-D-AspartateSchizophreniaHumansMental DisordersPhenotypeNR2B NMDA receptorReceptors, N-Methyl-D-AspartateADHDautismepilepsyGluN2AGluN2BGRIN2AGRIN2Bintellectual disabilitymutationsneurological disorderNMDA receptorsprecision medicinepsychiatric disordersschizophrenia

Identifiers

PMID31807283
PMCPMC6871362
OpenAlexW2989882319

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.