Evidence map›Paper›PMID 31807254›Full record

ArticleIranian journal of basic medical sciences2019

Attenuation by l-thyroxine of oxidant-induced gut epithelial damage.

Zahra Shahedi, Masoumeh Varedi, Zohreh Bagheri, Afagh Moatari, Hengameh Sharafpour

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Iranian journal of basic medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

  1. Necrotizing Enterocolitis: Overview on In Vitro Models.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Zahra ShahediDepartment of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Masoumeh VarediDepartment of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Zohreh BagheriDepartment of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Afagh MoatariDepartment of Microbiology & Virology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Hengameh SharafpourDepartment of Physiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran.
Shiraz University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesSevere injuries are often associated with tissue hypothyroidism, elevated damaging mediators in circulation, and broken gut epithelial barrier. However, the relationships between the hypothyroid state and gut epithelial damage are largely unknown. Therefore, in this study, we investigated the effects of L-thyroxine (T4) on MATERIALS AND

methodsGut epithelium equivalent was generated by cultivation of IEC-18 rat intestinal epithelial cells into transwell inserts. Confluent cultures were then compromised by scratching or H

resultsBoth H

conclusionThese data suggest that different mechanisms are involved in oxidant- and trauma-induced gut epithelial barrier breakdown. Besides, they show that T4 markedly attenuates oxidant-induced gut epithelial damage. Accordingly, one may also conclude that tissue hypothyroidism does not contribute to trauma-induced gut barrier breakdown.

Indexed as

Epithelial barriersGutOxidative stressThyroid hormonesTrauma

Identifiers

PMID31807254
PMCPMC6880525
OpenAlexW2976877103

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.