ArticleIranian journal of basic medical sciences2019
Behavioral and electrophysiological aspects of cognition in neonate rats lactated by morphine addicted mothers.
Article in Iranian journal of basic medical sciences, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Prenatal morphine exposure induces molecular and structural alterations in the developing hippocampus of neonatal rats.Iranian journal of basic medical sciences · 2026Article
- Effects of prenatal opioid exposure on synaptic adaptations and behaviors across development.Neuropharmacology · 2023Review
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Authors and funding
5 authors.
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Abstract
objectivesIn addition to genetic factors, environmental phenomena during postnatal age highly affect development and, in turn, function of the brain. The present work evaluates if morphine consumption during lactation period influences the spatial performances and synaptic plasticity in rats at neonatal period of age. MATERIALS AND
methodsThree groups of mothers were subcutaneously administered by 5 (M5), 10 (M10) or 20 (M20) mg/kg morphine every 12 hours during the lactation period. At 45 days old, their offspring were introduced to Morris water maze for assessment of spatial learning and memory. Basic field excitatory post-synaptic potentials (fEPSPs) were recorded in the CA1 area of hippocampus and, then, long term potentiation (LTP) was induced by tetanic stimulation.
resultsWe found that the M10 and M20 rats spent more time and traveled longer distance to find the hidden platform of maze when compared to the control animals (
conclusionThe present study provides behavioral and electrophysiological proofs for negative effect of morphine on the hippocampal-related function in the neonatally morphine-exposed rats.
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