Evidence map›Paper›PMID 31807213›Full record

ArticleBeilstein journal of organic chemistry2019

An improved, scalable synthesis of Notum inhibitor LP-922056 using 1-chloro-1,2-benziodoxol-3-one as a superior electrophilic chlorinating agent.

Nicky J Willis, Elliott D Bayle, George Papageorgiou, David Steadman, Benjamin N Atkinson, William Mahy, Paul V Fish

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Beilstein journal of organic chemistry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Borylcyclopropanes: Synthetic Strategies and Applications.Angewandte Chemie (International ed. in English) · 2026
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nicky J WillisAlzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.ORCID https://orcid.org/0000-0003-3245-5280
Elliott D BayleAlzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.
George PapageorgiouThe Francis Crick Institute, 1 Midland Road, Kings Cross, London NW1 1AT, UK.ORCID https://orcid.org/0000-0002-8960-5836
David SteadmanAlzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.ORCID https://orcid.org/0000-0003-4271-5525
Benjamin N AtkinsonAlzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.ORCID https://orcid.org/0000-0001-5511-9859
William MahyAlzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.
Paul V FishAlzheimer's Research UK UCL Drug Discovery Institute, The Cruciform Building, University College London, Gower Street, London WC1E 6BT, UK.ORCID https://orcid.org/0000-0002-2117-2173
Alzheimer’s Research UK · GBThe Francis Crick Institute · GB

Funding

Wellcome Trust FC001002
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

1-chloro-1,2-benziodoxol-3-onebrain penetrationelectrophilic chlorinationLP-922056Notum inhibitor

Identifiers

PMID31807213
PMCPMC6880826
OpenAlexW2969033390

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.