ArticleOncoTargets and therapy2019
Individualized Prediction Of Metastatic Involvement Of Lymph Nodes Posterior To The Right Recurrent Laryngeal Nerve In Papillary Thyroid Carcinoma.
Article in OncoTargets and therapy, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 14 citations in OpenAlex.
- Development and internal validation of a nomogram for predicting lymph node metastasis posterior to the right recurrent laryngeal nerve in papillary thyroid carcinoma: a single-center retrospective study.Frontiers in endocrinology · 2026Article
- Clinicopathological predictors of right para esophageal lymph node metastasis in papillary thyroid carcinoma: A systematic review and meta-analysis.World journal of clinical oncology · 2025Article
- Machine learning and Shapley Additive exPlanations to predict metastasis of lymph nodes posterior to the recurrent laryngeal nerve in cN0 papillary thyroid carcinoma.Frontiers in oncology · 2025Article
- Explainable machine learning model for predicting paratracheal lymph node metastasis in cN0 papillary thyroid cancer.Scientific reports · 2024Article
- Risk Factors for Right Paratracheal Posterolateral Lymph Node Metastasis in Papillary Thyroid Cancer.Sisli Etfal Hastanesi tip bulteni · 2024Article
- The incidence and features of Delphian lymph node involvement in patients with papillary thyroid carcinoma.BMC surgery · 2022Article
- Pattern and Predictive Factors of Metastasis in Lymph Nodes Posterior to the Right Recurrent Laryngeal Nerve in Papillary Thyroid Carcinoma.Frontiers in endocrinology · 2022Article
- Male Gender Is Associated with Lymph Node Metastasis but Not with Recurrence in Papillary Thyroid Carcinoma.International journal of endocrinology · 2022Article
- Proteomic Analysis Explores Interactions betweenMicroorganisms · 2021Article
- A meta-analysis of risk factors for lymph node posterior to the right recurrent laryngeal nerve metastasis in papillary thyroid carcinoma.Gland surgery · 2021Article
- Carbon nanoparticle-guided intraoperative lymph node biopsy predicts the status of lymph nodes posterior to right recurrent laryngeal nerve in cN0 papillary thyroid carcinoma.Gland surgery · 2021Article
- Clinical implications of Delphian lymph node metastasis in papillary thyroid carcinoma.Gland surgery · 2021Article
- Application of Machine Learning Algorithms to Predict Central Lymph Node Metastasis in T1-T2, Non-invasive, and Clinically Node Negative Papillary Thyroid Carcinoma.Frontiers in medicine · 2021Article
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12 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeWe aimed to establish a prediction model based on preoperative clinicopathologic features and intraoperative frozen section examination for precise prediction of metastatic involvement of lymph nodes posterior to the right recurrent laryngeal nerve (LN-prRLN) in patients with papillary thyroid carcinoma (PTC).
methodsClinicopathologic data pertaining to patients with PTC who underwent initial thyroid surgery between July 2015 and December 2017 were collected from electronic medical records. Multivariate logistic regression analysis was performed to identify independent predictors of LN-prRLN metastasis for incorporation in the nomogram. The performance of the model was assessed using discriminative ability, calibration, and clinical application.
resultsA total of 592 patients were enrolled in this study. The LN-prRLN metastatic positivity was 19% (95% confidence interval [CI], 15.61-21.89%). On multivariate analysis, ultrasonography-reported LN status, extrathyroid extension, Delphian lymph node metastasis, and number of metastatic pretracheal and paratracheal lymph nodes were independent predictors of LN-prRLN metastasis. The nomogram showed good discriminative ability (C-index: 0.87; [95% CI, 0.84-0.91]; bias-corrected C-index: 0.86 [through bootstrapping validation]) and was well calibrated. The decision curve analysis indicated potential clinical usefulness of the nomogram.
conclusionThis study demonstrates that the risk of LN-prRLN metastasis in individual patients can be robustly predicted by a nomogram that integrates readily available preoperative clinicopathologic features and intraoperative frozen section examination. The nomogram may facilitate intraoperative decision-making for patients with PTC.
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