ArticleNature medicine2019
Undulating changes in human plasma proteome profiles across the lifespan.
Open access · greenAbstract read
In one paragraph
Article in Nature medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 609 papers, 2 of them syntheses that pooled it.
0numbers the graph read from it
0cells of the map it votes in
609citing papers in PubMed, 2 pooled it
41.4field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
609 citing papers in PubMed, 2 syntheses or guidelines pooled it, 935 citations in OpenAlex.
- Pooled it
- Circulating Proteomics and Risk of Atrial Fibrillation: A Systematic Review of Cohort Studies.Journal of cellular and molecular medicine · 2025Pooled it
- Proteomic and machine learning analysis predicts treatment response signatures in Myasthenia Gravis.Journal of translational medicine · 2026Trial
- Trial
- Interstitial fluid rejuvenation through young-donor plasma exchange in cognitively impaired patients: a pilot safety and feasibility study.GeroScience · 2026Article
- Proteomic insights into childhood adversity: Exploring biological mechanisms and cognitive outcomes in the CARDIA study.Brain, behavior, & immunity - health · 2026Article
- Computational Modeling of Neurotransmitter Cycling Predicts Human Brain Glutamate and GABA Dynamics in Response to Acute Administration of Exogenous Ketones.Neurochemical research · 2026Article
- Sex-stratified immune patterns across the canine lifespan and short-term responses to geroprotective interventions.Biogerontology · 2026Article
- Speech clocks decode dementia phenotypes, social exposome, and biological aging.Science advances · 2026Article
- Targeting innovative therapeutic approaches to the hallmarks of aging to combat Alzheimer's disease.Neural regeneration research · 2026Article
- Tissue-specific aging clocks map structured aging-modulatory drug-score patterns across 49 human tissue and cell-line categories.Biogerontology · 2026Article
- Age-adjusted machine learning identifies facial skin microbes associated with skin quality among Korean women.mSystems · 2026Article
- Structural brain indicators of cognitive performance in middle and late adulthood: The Human Connectome Project in Aging/Aging Adult Brain Connectome cohort.Neurobiology of aging · 2026Article
- Review
- A Circulating Proteomic Signature of Allostatic Load Is Associated with Multisystem Disease and Mortality.Proteomes · 2026Article
- Atlas of genetic architecture and exploratory temporal interaction networks of plasma protein-based organ and system aging.Nature communications · 2026Article
- Protein Variability Patterns in Ovarian Serous Carcinoma.International journal of molecular sciences · 2026Article
- Combating ageing beyond the cell: Emerging roles of extracellular proteostasis.The FEBS journal · 2026Review
- Proteome-wide Mendelian randomization identifies APOM and TNXB as actionable mediators of steroid-sensitive nephrotic syndrome.Pediatric nephrology (Berlin, Germany) · 2026Article
- Plasma Proteomic Signatures of Coagulopathy Following Traumatic Injury: Links to Biomechanics and Patient Outcomes.Shock (Augusta, Ga.) · 2026Article
549 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 5 countries.
Benoit LehallierDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. lehallib@stanford.edu.ORCID http://orcid.org/0000-0001-7452-3785
David GateDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Nicholas SchaumInstitute for Stem Cell Biology and Regenerative Medicine, Stanford University, Stanford, CA, USA.
Tibor NanasiDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Song Eun LeeDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Hanadie YousefDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Patricia Moran LosadaDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Daniela BerdnikDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Andreas KellerClinical Bioinformatics, Saarland University, Saarbrücken, Germany.ORCID http://orcid.org/0000-0002-5361-0895
Joe VergheseInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Sanish SathyanInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Claudio FranceschiDepartment of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Sofiya MilmanInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Nir BarzilaiInstitute for Aging Research, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA.
Tony Wyss-CorayDepartment of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. twc@stanford.edu.ORCID http://orcid.org/0000-0001-5893-0831
Neurosciences Institute · USAlbert Einstein College of Medicine · USCalifornia Institute for Regenerative Medicine · USN. I. Lobachevsky State University of Nizhny Novgorod · RUSaarland University · DE
Funding
Einstein's Nathan Shock Center of Excellence in Basic Biology of AgingP30AG038072 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI VIJG, JAN · 2010 to 2024
$10.8MWorking Memory in Parkinson Disease: A Cognitive & Systems Neuroscience ApproachP50AG047366 · NIA · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2015 to 2019
$7.9MResilience to Alzheimer's disease in humans with exceptional longevityR01AG057909 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI BARZILAI, NIR J, ZHANG, ZHENGDONG · 2017 to 2021
$6.2MRole of exceptional longevity genotypes in protection against frailty in agingR01AG044829 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI Sofiya Milman, JOE VERGHESE · 2014 to 2026
$5.4MStanford Training Program in Aging ResearchT32AG047126 · NIA · STANFORD UNIVERSITY · PI VYJEYANTHI S PERIYAKOIL, TONY WYSS-CORAY · 2014 to 2026
$4.3MSomatotropic Signaling and Resilience to Aging and Alzheimer's DiseaseR01AG061155 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE · PI MILMAN, SOFIYA · 2019 to 2023
$4.3MA Bioorthogonal Approach to Study Mammalian AgingDP1AG053015 · NIA · STANFORD UNIVERSITY · PI WYSS-CORAY, TONY · 2015 to 2019
$3.7MCirculatory Rejuvenating Factors for the BrainR01AG045034 · NIA · PALO ALTO VETERANS INSTIT FOR RESEARCH · PI WYSS-CORAY, TONY · 2013 to 2017
$1.4MEffect of longevity genomes on the GH/IGF-1 phenotype and disease-free survivalK23AG051148 · NIA · ALBERT EINSTEIN COLLEGE OF MEDICINE, INC · PI MILMAN, SOFIYA · 2015 to 2018
$791kA novel blood-CSF adaptive immune response in Alzheimer's diseaseR00NS112458 · NINDS · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GATE, DAVID · 2022 to 2024
$740kA novel blood-CSF adaptive immune response in Alzheimer's diseaseK99NS112458 · NINDS · STANFORD UNIVERSITY · PI GATE, DAVID · 2020 to 2021
$245kReversing epigenetic changes in aged microglia via young circulatory factorsF32AG055255 · NIA · STANFORD UNIVERSITY · PI GATE, DAVID · 2018 to 2019
$68kBritish Heart Foundation RG/13/13/30194British Heart Foundation RG/18/13/33946Medical Research Council MR/L003120/1NIA NIH HHS DP1 AG053015NIA NIH HHS F32 AG055255NIA NIH HHS K23 AG051148NIA NIH HHS P30 AG038072NIA NIH HHS P50 AG047366NIA NIH HHS R01 AG044829NIA NIH HHS R01 AG045034NIA NIH HHS R01 AG057909NIA NIH HHS R01 AG061155NIA NIH HHS T32 AG047126NINDS NIH HHS K99 NS112458NINDS NIH HHS R00 NS112458
Abstract
Aging is a predominant risk factor for several chronic diseases that limit healthspan
Indexed as
AdolescentAdultAgedAged, 80 and overAgingAnimalsBlood ProteinsChronic DiseaseFemaleHumansLongevityMaleMiceMiddle AgedProteomeRisk FactorsBlood ProteinsProteome
Identifiers
What OpenQuestion holds
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.