Evidence map›Paper›PMID 31806625›Full record

ArticleDiabetes2020

Serotonin Regulates Adult β-Cell Mass by Stimulating Perinatal β-Cell Proliferation.

Joon Ho Moon, Yeong Gi Kim, Kyuho Kim, Sho Osonoi, Shuang Wang, Diane C Saunders, Juehu Wang, Katherine Yang, Hyeongseok Kim, Junguee Lee and 8 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 55 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

18 authors at 10 institutions in 4 countries.

Joon Ho MoonGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Yeong Gi KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Kyuho KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Sho OsonoiDepartment of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.
Shuang WangInstitute of Genome Engineered Animal Models for Human Disease and National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China.
Diane C SaundersDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.
Juehu WangEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Diabetes Center and Hormone Research Institute, University of California, San Francisco, San Francisco, CA.
Katherine YangEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Diabetes Center and Hormone Research Institute, University of California, San Francisco, San Francisco, CA.
Hyeongseok KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea.
Junguee LeeDepartment of Pathology, Daejeon St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Daejeon, Korea.
Ji-Seon JeongCenter for Bioanalysis, Division of Chemical and Medical Metrology, Korea Research Institute of Standards and Science, Daejeon, Korea.
Ronadip R BanerjeeDivision of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Alabama School of Medicine, Birmingham, AL.
Seung K KimDepartment of Developmental Biology, Stanford University School of Medicine, Palo Alto, CA.
Yingjie WuInstitute of Genome Engineered Animal Models for Human Disease and National Center of Genetically Engineered Animal Models for International Research, Dalian Medical University, Dalian, Liaoning, China.
Hiroki MizukamiDepartment of Pathology and Molecular Medicine, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.ORCID 0000-0003-2920-582X
Alvin C PowersDivision of Diabetes, Endocrinology, and Metabolism, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN.ORCID 0000-0003-1941-5786
Michael S GermanEli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Diabetes Center and Hormone Research Institute, University of California, San Francisco, San Francisco, CA hailkim@kaist.edu mgerman@ucsf.edu.
Hail KimGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology, Daejeon, Korea hailkim@kaist.edu mgerman@ucsf.edu.ORCID 0000-0002-6652-1349
Korea Advanced Institute of Science and Technology · KRUniversity of California, San Francisco · USDalian Medical University · CNHirosaki University · JPKorea Research Institute of Standards and Science · KRStanford University · USThe Catholic University of Korea Daejeon St. Mary's Hospital · KRUniversity of Alabama at Birmingham · USVanderbilt University Medical Center · USVA Tennessee Valley Healthcare System · US

Funding

Vanderbilt Diabetes Research CenterP30DK020593 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI ALVIN C POWERS · 2012 to 2026
$29.3M
Research BaseP30DK063720 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI VAISSE, CHRISTIAN · 2003 to 2019
$21.8M
Discovery of Pancreatic Signatures in Type 2 Diabetes MellitusR24DK106755 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI CAI, LONG, CAPRIOLI, RICHARD M · 2015 to 2019
$6.2M
High-resolution analysis of juvenile human pancreas maturationUC4DK108120 · NIDDK · VANDERBILT UNIVERSITY · PI CAI, LONG, GRADINARU, VIVIANA · 2015 to 2015
$4.4M
Molecular Mechanisms of Physiologic Beta Cell Growth in Juvenile Human PancreasUC4DK104211 · NIDDK · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIM, SEUNG K, POWERS, ALVIN C · 2014 to 2015
$4.0M
Islet alterations in type 2 diabetesI01BX000666 · VA · VETERANS HEALTH ADMINISTRATION · PI POWERS, ALVIN C · 2011 to 2025
–
BLRD VA I01 BX000666NIDDK NIH HHS P30 DK020593NIDDK NIH HHS P30 DK063720NIDDK NIH HHS R24 DK106755NIDDK NIH HHS UC4 DK104211NIDDK NIH HHS UC4 DK108120
6 · The paper itself

Abstract

A sufficient β-cell mass is crucial for preventing diabetes, and perinatal β-cell proliferation is important in determining the adult β-cell mass. However, it is not yet known how perinatal β-cell proliferation is regulated. Here, we report that serotonin regulates β-cell proliferation through serotonin receptor 2B (HTR2B) in an autocrine/paracrine manner during the perinatal period. In β-cell-specific

Indexed as

AnimalsAnimals, NewbornCell ProliferationFemaleGlucoseGrowth HormoneHumansInfantInsulin-Secreting CellsMiceMice, KnockoutPregnancyPropafenoneReceptors, ProlactinRNA, MessengerSerotoninGlucoseGrowth HormonePropafenoneReceptors, ProlactinRNA, MessengerSerotoninTph1 protein, mouseTryptophan Hydroxylase

Identifiers

PMID31806625
PMCPMC6971487
OpenAlexW2993252030

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.