ArticleNeuron2020
A Genetic Model of the Connectome.
Article in Neuron, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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Who cites it
27 citing papers in PubMed.
- A data-driven framework linking the connectome to spatial gene expression gradients inspired by chemoaffinity theory.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The structural grammar of integration and competition in the human connectome.Frontiers in computational neuroscience · 2026Article
- Article
- Building the connectome of a small brain with a simple stochastic developmental generative model.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Molecular architecture of language-related cortical areas revealed by integrative proteomic and connectome analyses.Clinical and translational medicine · 2025Article
- Structural and genetic determinants of zebrafish functional brain networks.Science advances · 2025Article
- Three systems of circuit formation: assembly, updating and tuning.Nature reviews. Neuroscience · 2025Review
- Decoding neuronal wiring by joint inference of cell identity and synaptic connectivity.bioRxiv : the preprint server for biology · 2025Article
- Scrutinizing neurodegenerative diseases: decoding the complex genetic architectures through a multi-omics lens.Human genomics · 2024Review
- Encoding innate ability through a genomic bottleneck.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Article
- Functional neuronal circuits emerge in the absence of developmental activity.Nature communications · 2024Article
- Neuroscience Needs Network Science.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Neuroscience needs Network Science.ArXiv · 2023Article
- Complex computation from developmental priors.Nature communications · 2023Article
- Article
- Evolution of central neural circuits: state of the art and perspectives.Nature reviews. Neuroscience · 2022Review
- Bringing Anatomical Information into Neuronal Network Models.Advances in experimental medicine and biology · 2022Article
- A Transcriptome Community-and-Module Approach of the Human Mesoconnectome.Entropy (Basel, Switzerland) · 2021Article
- Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
The connectomes of organisms of the same species show remarkable architectural and often local wiring similarity, raising the question: where and how is neuronal connectivity encoded? Here, we start from the hypothesis that the genetic identity of neurons guides synapse and gap-junction formation and show that such genetically driven wiring predicts the existence of specific biclique motifs in the connectome. We identify a family of large, statistically significant biclique subgraphs in the connectomes of three species and show that within many of the observed bicliques the neurons share statistically significant expression patterns and morphological characteristics, supporting our expectation of common genetic factors that drive the synapse formation within these subgraphs. The proposed connectome model offers a self-consistent framework to link the genetics of an organism to the reproducible architecture of its connectome, offering experimentally falsifiable predictions on the genetic factors that drive the formation of individual neuronal circuits.
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