Evidence map›Paper›PMID 31805985›Full record

ArticleTrials2019

Solar-powered oxygen delivery for the treatment of children with hypoxemia: protocol for a cluster-randomized stepped-wedge controlled trial in Uganda.

Nicholas Conradi, Qaasim Mian, Sophie Namasopo, Andrea L Conroy, Laura L Hermann, Charles Olaro, Jackson Amone, Robert O Opoka, Michael T Hawkes

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03851783 (Effect of Solar Powered Oxygen Delivery on Childhood Mortality in Uganda), which is not on this map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.5field-weighted citation impact, top 28% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03851783 nacompletednot on this map

Effect of Solar Powered Oxygen Delivery on Childhood Mortality in Uganda: A Cluster-Randomized Trial

TypeinterventionalSponsorUniversity of AlbertaRan2019 to 2021Enrolled2,405ConditionsPneumonia, HypoxemiaArmsSolar-powered oxygen
3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Nicholas ConradiDepartment of Pediatrics, University of Alberta, 3-588D Edmonton Clinic Health Academy, 11405 87 Ave NW, Edmonton, Alberta, T6G 1C9, Canada.
Qaasim MianDepartment of Pediatrics, University of Alberta, 3-588D Edmonton Clinic Health Academy, 11405 87 Ave NW, Edmonton, Alberta, T6G 1C9, Canada.
Sophie NamasopoKabale Regional Referral Hospital, Kabale, Uganda.
Andrea L ConroyIndiana University, Indianapolis, USA.
Laura L HermannKelowna General Hospital, Kelowna, Canada.
Charles OlaroMinistry of Health, Kampala, Uganda.
Jackson AmoneMinistry of Health, Kampala, Uganda.
Robert O OpokaDepartment of Paediatrics and Child Health, Mulago Hospital and Makerere University, Kampala, Uganda.
Michael T HawkesDepartment of Pediatrics, University of Alberta, 3-588D Edmonton Clinic Health Academy, 11405 87 Ave NW, Edmonton, Alberta, T6G 1C9, Canada. mthawkes@ualberta.ca.ORCID http://orcid.org/0000-0002-4122-0937
University of Alberta · CAMinistry of Health · UGIndiana University – Purdue University Indianapolis · USKabale Hospital · UGKelowna General Hospital · CAMulago Hospital · UG

Funding

Grand Challenges Canada GCC 0486-01-10Women and Children's Health Research Institute 308315
6 · The paper itself

Abstract

backgroundChild mortality due to pneumonia is a major global health problem and is associated with hypoxemia. Access to safe and continuous oxygen therapy can reduce mortality; however, low-income countries may lack the necessary resources for oxygen delivery. We have previously demonstrated proof-of-concept that solar-powered oxygen (SPO

methodsObjectives: Demonstrate efficacy of SPO STUDY

designMulti-center, stepped-wedge cluster-randomized trial.

settingTwenty health facilities across Uganda, a low-income, high-burden country for pediatric pneumonia. Site selection: Facilities with pediatric inpatient services lacking consistent O

participantsChildren aged < 5 years hospitalized with hypoxemia (saturation < 92%) warranting hospital admission based on clinical judgement. Randomization methods: Random installation order generated a priori with allocation concealment. Study procedure: Patients receive standard of care within pediatric wards with or without SPO OUTCOME MEASURES: Primary: 48-h mortality. Secondary: safety, efficacy, SPO SAMPLE SIZE: 2400 patients across 20 health facilities, predicted to provide 80% power to detect a 35% reduction in mortality after introduction of SPO DISCUSSION: Overall, our study aims to demonstrate mortality benefit of SPO

trial registrationClinicaltrials.gov, NCT03851783. Registered on 22 February 2019.

Indexed as

HypoxiaOxygen Inhalation TherapySolar EnergyChild, PreschoolHumansInfantInfant, NewbornMulticenter Studies as TopicOutcome Assessment, Health CareOxygenRandomized Controlled Trials as TopicResearch DesignSample SizeOxygenHypoxemiaPediatric pneumoniaSolar oxygen

Identifiers

PMID31805985
PMCPMC6896330
OpenAlexW2993322394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.