Evidence map›Paper›PMID 31805903›Full record

ArticleBMC pulmonary medicine2019

Effect of exogenous surfactant on Paediatric Bronchoalveolar lavage derived macrophages' cytokine secretion.

Lyné van Rensburg, Johann M van Zyl, Johan Smith, Pierre Goussard

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pulmonary medicine, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.7field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. The Inhibitory Effect of CurosurfFrontiers in immunology · 2020
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Lyné van RensburgDivision of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences Stellenbosch University, PO Box 241, 8000; Francie van Zijl Drive, Cape Town, Tygerberg, 7505, South Africa.
Johann M van ZylDivision of Clinical Pharmacology, Department of Medicine, Faculty of Medicine and Health Sciences Stellenbosch University, PO Box 241, 8000; Francie van Zijl Drive, Cape Town, Tygerberg, 7505, South Africa. jmvzyl@sun.ac.za.ORCID http://orcid.org/0000-0003-0888-8684
Johan SmithDepartment of Pediatrics, Tygerberg Children's Hospital, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa.
Pierre GoussardDepartment of Pediatrics, Tygerberg Children's Hospital, Faculty of Medicine and Health Sciences, Stellenbosch University, Tygerberg, 7505, South Africa.
Stellenbosch University · ZA

Funding

Universiteit Stellenbosch None
6 · The paper itself

Abstract

backgroundBronchoalveolar lavage is a useful bronchoscopy technique. However, studies in "normal" children populations are few. Furthermore, the anti-inflammatory effects of exogenous pulmonary surfactants on the bronchoalveolar cellular components are limited.

methodsThirty children, aged 3 to 14 years, underwent diagnostic bronchoscopy and bronchoalveolar lavage. Differential cytology, cytokine and chemokine measurements were performed on the fluid after exogenous surfactant exposure. The aim of the study was to investigate the potential anti-inflammatory effects of exogenous surfactants on the bronchoalveolar lavage fluid, specifically alveolar macrophages of healthy South African children.

resultsAlveolar macrophages were the predominant cellular population in normal children. Patients with inflammatory pneumonopathies had significantly more neutrophils. Levels of inflammatory cytokines were significantly lower after exogenous surfactant exposure. Moreover, IL-10 and IL-12 cytokine secretion increased after exogenous surfactant exposure.

conclusionThis study provides the first data on bronchoalveolar lavage of healthy South African children. Bronchoalveolar lavage fluid from patients with pulmonary inflammation was characterised by neutrophilia. Finally, we propose that exogenous surfactant treatment could help alleviate inflammation in diseased states where it occurs in the tracheobronchial tree.

Indexed as

AdolescentBronchoalveolar LavageBronchoalveolar Lavage FluidBronchoscopyChildChild, PreschoolCytokinesFemaleHealthy VolunteersHumansLeukocyte CountMacrophages, AlveolarMalePulmonary SurfactantsSouth AfricaCytokinesPulmonary SurfactantsAlveolar macrophagesBronchoalveolar lavageBronchoscopyCytokines

Identifiers

PMID31805903
PMCPMC6896770
OpenAlexW2994067054

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.