Evidence map›Paper›PMID 31805899›Full record

ArticleBMC psychiatry2019

Association of Borderline Intellectual Functioning and Adverse Childhood Experience with adult psychiatric morbidity. Findings from a British birth cohort.

Angela Hassiotis, Emma Brown, James Harris, David Helm, Kerim Munir, Luis Salvador-Carulla, Marco Bertelli, Amaria Baghdadli, Jannelien Wieland, Ramon Novell-Alsina and 6 more

Open access · goldAbstract read
In one paragraph

Article in BMC psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.9field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Article
  3. Understanding Adaptive Skills in Borderline Intellectual Functioning: A Systematic Review.European journal of investigation in health, psychology and education · 2025
    Review
  4. Article
  5. Etiology of Borderline Intellectual Functioning.Journal of the Korean Academy of Child and Adolescent Psychiatry · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Frontiers in neuroscience · 2021
    Article
  12. Article
  13. Article
  14. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 11 institutions in 8 countries.

Angela HassiotisDivision of Psychiatry, University College London, 149 Tottenham Court Road, London, W1T 7NF, UK. a.hassiotis@ucl.ac.uk.ORCID 0000-0002-9800-3909
Emma BrownDivision of Psychiatry, University College London, 149 Tottenham Court Road, London, W1T 7NF, UK.
James HarrisDevelopmental Neuropsychiatry, Department of Psychiatry and Behavioral Sciences, Bloomberg Children's Center, The Johns Hopkins Hospital, Baltimore, MD, USA.
David HelmInstitute for Community Inclusion, Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.
Kerim MunirInstitute for Community Inclusion, Division of Developmental Medicine, Boston Children's Hospital, Boston, MA, USA.
Luis Salvador-CarullaCentre for Mental Health Research, Australian National University, Acton, Australia.
Marco BertelliCREA, Research and Clinical Centre, San Sebastiano Foundation, Florence, Italy.
Amaria BaghdadliChild and Adolescent Psychiatry Department, Montpellier Hospital University, Montpellier, France.
Jannelien WielandKristal Centre for Psychiatry and Intellectual Disability, Rivierduinen, Leiden, The Netherlands.
Ramon Novell-AlsinaMental Health and Intellectual Disability Specialized Service, Catalan Health Govenment. Martí i Julià Hospital, Girona, Spain.
Jordi CidMental Health and Intellectual Disability Specialized Service, Catalan Health Govenment. Martí i Julià Hospital, Girona, Spain.
Laura VergésMental Health and Intellectual Disability Specialized Service, Catalan Health Govenment. Martí i Julià Hospital, Girona, Spain.
Rafael Martínez-LealIntellectual Disability and Developmental Disorders Research Unit (UNIVIDD), Fundació Villablanca, IISPV, Universitat Rovira i Virgili, CIBERSAM, Reus, Spain.
Tuba MutluerDepartment of Child and Adolescent Psychiatry, Koc University Hospital, Istanbul, Turkey.
Fuad IsmayilovDepartment of Psychiatry, Azerbaijan Medical University, Baku, Azerbaijan.
Eric EmersonCentre for Disability Research & Policy, Faculty of Health Sciences, University of Sydney, Sydney, Australia.
Boston Children's Hospital · USAustralian National University · AUAzerbaijan Medical University · AZBloomberg (United States) · USCentre Hospitalier Universitaire de Montpellier · FRGGZ Rivierduinen · NLInstitut de Recerca Biomèdica Catalunya Sud · ESKoç University · TRThe London College · GBThe University of Sydney · AUUniversity College London · GB

Funding

Department of Health RP-DG-0611-10003
6 · The paper itself

Abstract

backgroundTo examine whether Borderline Intellectual Functioning (BIF) and Adverse Childhood Experiences independently predict adult psychiatric morbidity.

methodsWe performed a secondary analysis of longitudinal data derived from the 1970 British Birth Cohort Study to examine whether BIF and Adverse Childhood Experiences independently predict adult mental distress as measured by the Malaise Inventory. Factor analysis was used to derive a proxy measure of IQ from cognitive testing at age 10 or 5. Variables that could be indicators of exposure to Adverse Childhood Experiences were identified and grouped into health related and socio-economic related adversity.

resultsChildren with BIF were significantly more likely than their peers to have been exposed to Adverse Childhood Experiences (BIF mean 5.90, non-BIF mean 3.19; Mann-Whitney z = 31.74, p < 0.001). As adults, participants with BIF were significantly more likely to score above the cut-off on the Malaise Inventory. We found statistically significant relationships between the number of socio-economic Adverse Childhood Experiences and poorer adult psychiatric morbidity (r range 0.104-0.141, all p < 001). At all ages the indirect mediating effects of Adverse Childhood Experiences were significantly related to adult psychiatric morbidity.

conclusionsThe relationship between BIF and adult psychiatric morbidity appears to be partially mediated by exposure to Adverse Childhood Experiences. Where possible, targeting Adverse Childhood Experiences through early detection, prevention and interventions may improve psychiatric morbidity in this population group.

Indexed as

AdultAdult Survivors of Child AbuseAdverse Childhood ExperiencesCohort StudiesComorbidityEnglandFemaleHumansIntellectual DisabilityMaleMental DisordersPrevalenceAdversityBorderlineChildhoodIntellectualMental wellbeing

Identifiers

PMID31805899
PMCPMC6896708
OpenAlexW2993207950

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.