Evidence map›Paper›PMID 31805382›Full record

ArticleNeuroImage2020

State and trait characteristics of anterior insula time-varying functional connectivity.

Lorenzo Pasquini, Gianina Toller, Adam Staffaroni, Jesse A Brown, Jersey Deng, Alex Lee, Katarzyna Kurcyus, Suzanne M Shdo, Isabel Allen, Virginia E Sturm and 9 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in NeuroImage, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 4 institutions in 2 countries.

Lorenzo PasquiniMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Gianina TollerMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Adam StaffaroniMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Jesse A BrownMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Jersey DengMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Alex LeeMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Katarzyna KurcyusDepartment of Neuroradiology, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany; Department of Nuclear Medicine, Klinikum Rechts der Isar, Technische Universität München, Munich, Germany.
Suzanne M ShdoPsychology, University of California Berkeley, USA.
Isabel AllenMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Virginia E SturmMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Yann CobigoMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Valentina BorghesaniMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Giovanni BattistellaMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Maria Luisa Gorno-TempiniMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Katherine P RankinMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Joel KramerMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Howard H RosenMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
Bruce L MillerMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA.
William W SeeleyMemory and Aging Center, Department of Neurology, University of California, San Francisco, CA, USA; Memory and Aging Center, Department of Pathology, University of California, San Francisco, CA, USA. Electronic address: bill.seeley@ucsf.edu.
University of California, San Francisco · USUniversity Memory and Aging Center · USTechnical University of Munich · DEUniversity of California, Berkeley · US

Funding

TDP-43 Loss-of-Function: Biology to BiomarkersP01AG019724 · NIA · UNIVERSITY OF PENNSYLVANIA · PI Jennifer Merrilees · 2002 to 2026
$67.2M
PrPSc SPECIFIC INTERACTION WITH NOVEL PrP-Fc FUSION PROTEINSP50AG023501 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MILLER, BRUCE L · 2004 to 2018
$27.1M
Progressive Aphasia Cognition Anatomy and ProgressionR01NS050915 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI · 2004 to 2026
$11.0M
Mechanisms of Executive Decline in Normal AgingR01AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Kaitlin B Casaletto, JOEL H KRAMER · 2009 to 2026
$8.3M
Emotion network dysfunction and decline in early frontotemporal dementiaR01AG052496 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Virginia Emily Sturm · 2017 to 2026
$6.9M
Connectomic imaging in familial and sporadic frontotemporal degenerationU01AG052943 · NIA · UNIVERSITY OF PENNSYLVANIA · PI GORNO TEMPINI, MARIA LUISA, GROSSMAN, MURRAY · 2016 to 2019
$5.9M
Biological Predictors Of Brain Aging Trajectories Diversity Supplement: African American Outreach And The Intersection Between Social Determinants Of Health And Biomarkers Of Degenerative DiseaseRF1AG032289 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2020 to 2021
$5.3M
Neurobiological Basis of Emotion Regulation Trajectories in Early Alzheimer's DiseaseR01AG057204 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI STURM, VIRGINIA EMILY · 2017 to 2021
$3.9M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaR01NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI MARIA LUISA GORNO TEMPINI, John Francis Houde · 2017 to 2026
$3.6M
Effects of chronic inflammation on brain structure and functionR01AG048234 · NIA · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI KRAMER, JOEL H · 2015 to 2019
$3.2M
Dynamic Brain Imaging of Speech in Primary Progressive AphasiaRF1NS100440 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA, HOUDE, JOHN FRANCIS · 2023 to 2023
$2.4M
Training program in the neurology of language and neurodegenerative aphasiasK24DC015544 · NIDCD · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GORNO TEMPINI, MARIA LUISA · 2016 to 2025
$1.9M
NIA NIH HHS K01 AG055698NIA NIH HHS K23 AG061253NIA NIH HHS P01 AG019724NIA NIH HHS P50 AG023501NIA NIH HHS R01 AG032289NIA NIH HHS R01 AG048234NIA NIH HHS R01 AG052496NIA NIH HHS R01 AG057204NIA NIH HHS RF1 AG032289NIA NIH HHS U01 AG052943NIDCD NIH HHS K24 DC015544NINDS NIH HHS R01 NS050915NINDS NIH HHS R01 NS100440NINDS NIH HHS R56 NS050915NINDS NIH HHS RF1 NS100440
6 · The paper itself

Abstract

The human anterior insula (aINS) is a topographically organized brain region, in which ventral portions contribute to socio-emotional function through limbic and autonomic connections, whereas the dorsal aINS contributes to cognitive processes through frontal and parietal connections. Open questions remain, however, regarding how aINS connectivity varies over time. We implemented a novel approach combining seed-to-whole-brain sliding-window functional connectivity MRI and k-means clustering to assess time-varying functional connectivity of aINS subregions. We studied three independent large samples of healthy participants and longitudinal datasets to assess inter- and intra-subject stability, and related aINS time-varying functional connectivity profiles to dispositional empathy. We identified four robust aINS time-varying functional connectivity modes that displayed both "state" and "trait" characteristics: while modes featuring connectivity to sensory regions were modulated by eye closure, modes featuring connectivity to higher cognitive and emotional processing regions were stable over time and related to empathy measures.

Indexed as

Psychosocial FunctioningAdultAgedAged, 80 and overCerebral CortexCluster AnalysisConnectomeCross-Sectional StudiesDatasets as TopicEmpathyFemaleHumansLongitudinal StudiesMagnetic Resonance ImagingMaleMiddle AgedAnterior insulaSocio-emotional functioningStateTime-varying functional connectivityTrait

Identifiers

PMID31805382
PMCPMC7225015
OpenAlexW2989640633

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.