Evidence map›Paper›PMID 31805259›Full record

ArticleNeuron2019

Relax, Don't RAN Translate It.

Katherine M Wilson, Bhavana Muralidharan, Adrian M Isaacs

Abstract readComment
PubMed Publisher
In one paragraph

Article in Neuron, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Translational control in aging and neurodegeneration.Wiley interdisciplinary reviews. RNA · 2021
    Review
  3. Lost in Translation: When the Rules Do Not Apply.Wiley interdisciplinary reviews. RNA
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Katherine M WilsonUK Dementia Research Institute at UCL, Gower Street, London WC1E 6BT, UK; Department of Neurodegenerative Disease, Queen Square UCL Institute of Neurology, London WC1N 3BG, UK.
Bhavana MuralidharanUK Dementia Research Institute at UCL, Gower Street, London WC1E 6BT, UK; Department of Neurodegenerative Disease, Queen Square UCL Institute of Neurology, London WC1N 3BG, UK; Brain Development and Disease Mechanisms, Institute for Stem Cell Biology and Regenerative Medicine (inStem), Bangalore, India, 560065.
Adrian M IsaacsUK Dementia Research Institute at UCL, Gower Street, London WC1E 6BT, UK; Department of Neurodegenerative Disease, Queen Square UCL Institute of Neurology, London WC1N 3BG, UK. Electronic address: a.isaacs@ucl.ac.uk.

Funding

Motor Neurone Disease Association ISAACS/APR15/834-791
6 · The paper itself

Abstract

The (GGGGCC)n repeat expansion in C9orf72, which is the most common cause of frontotemporal dementia and amyotrophic lateral sclerosis, is translated through repeat-associated non-AUG (RAN) translation. In this issue of Neuron, Cheng et al. (2019) report that the helicase DDX3X, which unwinds (or relaxes) RNA, suppresses RAN translation and toxicity.

Indexed as

Amyotrophic Lateral SclerosisC9orf72 ProteinCRISPR-Cas SystemsDEAD-box RNA HelicasesDNA Repeat ExpansionFrontotemporal DementiaHumansRNA HelicasesC9orf72 ProteinC9orf72 protein, humanDDX3X protein, humanDEAD-box RNA HelicasesRNA Helicases

Identifiers

PMID31805259

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.