Evidence map›Paper›PMID 31805207›Full record

ArticleAmerican journal of hematology2020

S100B has pleiotropic effects on vaso-occlusive manifestations in sickle cell disease.

Xu Zhang, Binal N Shah, Wei Zhang, Santosh L Saraf, Mehdi Nouraie, Sergei Nekhai, Roberto F Machado, Mark T Gladwin, Victor R Gordeuk

Open access · bronzeAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of hematology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
0.1field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Xu ZhangDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois.ORCID 0000-0002-7732-1385
Binal N ShahDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois.
Wei ZhangDepartment of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Santosh L SarafDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois.ORCID 0000-0002-8584-4194
Mehdi NouraieDivision of Pulmonary, Allergy, and Critical Care Medicine, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.ORCID 0000-0001-7465-0581
Sergei NekhaiCenter for Sickle Cell Disease, Howard University, Washington, District of Columbia.ORCID 0000-0003-0744-7887
Roberto F MachadoDivision of Pulmonary, Critical Care, Sleep, and Occupational Medicine, Department of Medicine, Indiana University, Indianapolis, Indiana.
Mark T GladwinDivision of Pulmonary, Allergy, and Critical Care Medicine, Vascular Medicine Institute, University of Pittsburgh, Pittsburgh, Pennsylvania.
Victor R GordeukDepartment of Medicine, University of Illinois at Chicago, Chicago, Illinois.ORCID 0000-0003-4725-7295
University of Illinois Chicago · USUniversity of Pittsburgh · USHoward University · USIndiana University – Purdue University Indianapolis · USNorthwestern University · US

Funding

UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
UCLA Clinical and Translational Science InstituteUL1TR000124 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2012 to 2015
$57.0M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
UCLA CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTEUL1RR033176 · NCRR · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI DUBINETT, STEVEN M. · 2011 to 2011
$15.5M
Center for Clinical and Translational ScienceUL1TR000050 · NCATS · UNIVERSITY OF ILLINOIS AT CHICAGO · PI AZAR, DIMITRI T, MERMELSTEIN, ROBIN J. · 2012 to 2014
$9.8M
Exceptional Survival: Trajectories to Functional Aging (CHS All Stars)R01AG023629 · NIA · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI NEWMAN, ANNE B. · 2004 to 2016
$9.5M
CHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5M
Vascular Targeting Genomic & Genetic Strategies for Acute Chest SyndromeR01HL111656 · NHLBI · UNIVERSITY OF MARYLAND BALTIMORE · PI Roberto F. Machado · 2013 to 2026
$7.9M
Pulmonary Hypertension and the Hypoxic Response in SCDR01HL079912 · NHLBI · HOWARD UNIVERSITY · PI GORDEUK, VICTOR R · 2005 to 2008
$7.4M
Genome-wide case-only study of antihypertensive drug-gene interactionsR01HL085251 · NHLBI · UNIVERSITY OF WASHINGTON · PI PSATY, BRUCE M · 2007 to 2010
$7.2M
Center for Hemoglobin Research in Minorities (CHaRM)P50HL118006 · NHLBI · HOWARD UNIVERSITY · PI NEKHAI, SERGEI · 2013 to 2017
$7.0M
Sickle Cell Disease and Sickle Cell Trait Protection Against HIV-1-infection in Africans and African AmericansR01HL125005 · NHLBI · HOWARD UNIVERSITY · PI MARINA A JEREBTSOVA, SERGEI NEKHAI · 2014 to 2026
$6.7M
NCATS NIH HHS UL1 TR000050NCATS NIH HHS UL1 TR000124NCRR NIH HHS UL1 RR033176NHGRI NIH HHS U01 HG004402NHLBI NIH HHS K23 HL125984NHLBI NIH HHS N01 HB067189NHLBI NIH HHS N01 HC055222NHLBI NIH HHS N01 HC065226NHLBI NIH HHS N01 HC075150NHLBI NIH HHS N01 HC085079NHLBI NIH HHS N01 HC085080NHLBI NIH HHS N01 HC085081NHLBI NIH HHS N01 HC085082NHLBI NIH HHS N01 HC085083NHLBI NIH HHS N01 HC085085NHLBI NIH HHS N01 HC085086NHLBI NIH HHS P30 HL107253NHLBI NIH HHS P50 HL118006NHLBI NIH HHS R01 HL079912NHLBI NIH HHS R01 HL085251NHLBI NIH HHS R01 HL087652NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111656NHLBI NIH HHS R01 HL125005NHLBI NIH HHS R01 HL127342NHLBI NIH HHS R03 HL146788NHLBI NIH HHS R25 HL003679NHLBI NIH HHS U01 HL080295NHLBI NIH HHS UH1 HL003679NIA NIH HHS R01 AG023629NIDDK NIH HHS P30 DK063491
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Anemia, Sickle CellPolymorphism, Single NucleotideQuantitative Trait LociS100 Calcium Binding Protein beta SubunitVascular DiseasesAllelesCross-Sectional StudiesFemaleHumansMaleS100B protein, humanS100 Calcium Binding Protein beta Subunit

Identifiers

PMID31805207
PMCPMC7326008
OpenAlexW2992916812

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.