ArticleThe journals of gerontology. Series B, Psychological sciences and social sciences2021
Mortality and Obesity Among U.S. Older Adults: The Role of Polygenic Risk.
Article in The journals of gerontology. Series B, Psychological sciences and social sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 14 citations in OpenAlex.
- Weight-adjusted waist index and risk of cardiovascular and all-cause mortality in chronic kidney disease: NHANES 2005-2018 analysis of 5,381 adults.Renal failure · 2026Article
- A machine learning-derived polygenic risk score reveals that healthy lifestyle counteracts obesity-related mortality.NPJ digital medicine · 2026Article
- Genetic influences, lifestyle and psychosocial aspects in relation to metabolically healthy obesity and conversion to a metabolically unhealthy state.Diabetes, obesity & metabolism · 2025Article
- Association of weight-adjusted waist index with cardiovascular disease and mortality among metabolic syndrome population.Scientific reports · 2024Article
- Gene-environment interactions and the case of body mass index and obesity: How much do they matter?PNAS nexus · 2023Article
- Effects of Walking Speed on Total and Regional Body Fat in Healthy Postmenopausal Women.Nutrients · 2022Article
- The Role of Individualized Exercise Prescription in Obesity Management-Case Study.International journal of environmental research and public health · 2021Article
- Utilizing genome wide data to highlight the social behavioral pathways to health: The case of obesity and cardiovascular health among older adults.Social science & medicine (1982) · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
Abstract
objectivesTo examine the relationship between obesity and mortality as a function of polygenic risk for obesity among older U.S. adults.
methodUsing data from the 1994-2014 Health and Retirement Study in conjunction with genome-wide data, we evaluated the risk of mortality as a function of obesity classification, an individual's polygenic risk score (PGS) for obesity, and their interaction, stratified by sex. We conducted our analyses using cox proportional hazard models.
resultsAmong those with an average PGS for obesity (8,143 [68.8%]), obese I (hazard ratio [HR] = 0.79, p = .336) adults show no difference in their risk for mortality and obese II/III (HR = 3.17, p = .000) adults present higher risk of mortality relative to non-obese adults. The interaction of obesity classification and PGS suggests that obese II/III respondents with low PGS in the total sample (HR = 2.71, p = .006) and among women (HR = 3.02, p = .023) are at significantly higher risk of death when compared to obese II/III respondents with average or high PGS. DISCUSSION: We posit that these findings suggest that the pathway to obesity, in this case, more socio-behavioral rather than genetic, may influence subsequent risk of death in older adults. We suggest that practitioners and population researchers be mindful of these pathways as to better identify and understand mortality risk.
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