Evidence map›Paper›PMID 31805160›Full record

ArticlePloS one2019

Neuroimaging modality fusion in Alzheimer's classification using convolutional neural networks.

Arjun Punjabi, Adam Martersteck, Yanran Wang, Todd B Parrish, Aggelos K Katsaggelos, Alzheimer’s Disease Neuroimaging Initiative

Abstract read
In one paragraph

Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Hybrid multi-modality multi-task learning for forecasting progression trajectories in subjective cognitive decline.Neural networks : the official journal of the International Neural Network Society · 2025
    Article
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  11. Artificial intelligence for molecular neuroimaging.Annals of translational medicine · 2021
    Review
  12. Application and Construction of Deep Learning Networks in Medical Imaging.IEEE transactions on radiation and plasma medical sciences · 2021
    Article
  13. Article
  14. Article
  15. Review
  16. Interpretation of Brain Morphology in Association to Alzheimer's Disease Dementia Classification Using Graph Convolutional Networks on Triangulated Meshes.Shape in Medical Imaging : International Workshop, ShapeMI 2020, Held in Conjunction with MICCAI 2020, Lima, Peru, October 4, 2020, Proceedings · 2020
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Arjun PunjabiDepartment of Electrical Engineering and Computer Science/McCormick School of Engineering, Northwestern University, Evanston, Illinois, United States of America.ORCID 0000-0003-2770-3112
Adam MartersteckDepartment of Radiology/Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Yanran WangDepartment of Electrical Engineering and Computer Science/McCormick School of Engineering, Northwestern University, Evanston, Illinois, United States of America.
Todd B ParrishDepartment of Radiology/Feinberg School of Medicine, Northwestern University, Chicago, Illinois, United States of America.
Aggelos K KatsaggelosDepartment of Electrical Engineering and Computer Science/McCormick School of Engineering, Northwestern University, Evanston, Illinois, United States of America.
Alzheimer’s Disease Neuroimaging Initiative

Funding

Alzheimer's Disease Neuroimaging Initiative - SupplementU01AG024904 · NIA · NORTHERN CALIFORNIA INSTITUTE RES &EDUC · PI WEINER, MICHAEL W · 2004 to 2015
$121.0M
PREDOCTORAL AND POSTDOCTORAL TRAINING PROGRAM IN AGING AND DEMENTIAT32AG020506 · NIA · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROBERT J VASSAR, SANDRA WEINTRAUB · 2002 to 2026
$9.9M
Predoctoral Training Program in Biomedical Data Driven Discovery (BD3)T32LM012203 · NLM · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KLABJAN, DIEGO, STARREN, JUSTIN B. · 2015 to 2019
$1.1M
CIHRNIA NIH HHS T32 AG020506NIA NIH HHS U01 AG024904NLM NIH HHS T32 LM012203
6 · The paper itself

Abstract

Automated methods for Alzheimer's disease (AD) classification have the potential for great clinical benefits and may provide insight for combating the disease. Machine learning, and more specifically deep neural networks, have been shown to have great efficacy in this domain. These algorithms often use neurological imaging data such as MRI and FDG PET, but a comprehensive and balanced comparison of the MRI and amyloid PET modalities has not been performed. In order to accurately determine the relative strength of each imaging variant, this work performs a comparison study in the context of Alzheimer's dementia classification using the Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset with identical neural network architectures. Furthermore, this work analyzes the benefits of using both modalities in a fusion setting and discusses how these data types may be leveraged in future AD studies using deep learning.

Indexed as

NeuroimagingAgedAlzheimer DiseaseAmyloidFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMultimodal ImagingNeural Networks, ComputerPositron-Emission TomographyAmyloid

Identifiers

PMID31805160
PMCPMC6894831

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.