ArticlePloS one2019
Incidences of community onset severe sepsis, Sepsis-3 sepsis, and bacteremia in Sweden - A prospective population-based study.
Article in PloS one, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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21 citing papers in PubMed, 44 citations in OpenAlex.
- Biological Aging, Immune Phenotypes, and Susceptibility to COVID-19 and Sepsis: A Mendelian Randomization Study.Virus research · 2026Article
- Socioeconomic disparities and mortality among acute patients with sepsis: a retrospective Danish cohort study.BMJ open · 2026Article
- Identification of protein biomarkers to differentiate between gram-negative and gram-positive infections in adults suspected of sepsis.BMC infectious diseases · 2025Article
- Laboratory and Microbiological Considerations in Sepsis-Induced Cardiac Dysfunction.Medicina (Kaunas, Lithuania) · 2025Article
- Early prediction of sepsis associated encephalopathy in elderly ICU patients using machine learning models: a retrospective study based on the MIMIC-IV database.Frontiers in cellular and infection microbiology · 2025Article
- Re-visiting humoral constitutive antibacterial heterogeneity in bloodstream infections.The Lancet. Infectious diseases · 2024Review
- Predicting sepsis using a combination of clinical information and molecular immune markers sampled in the ambulance.Scientific reports · 2023Article
- Delayed Treatment of Bloodstream Infection at Admission is Associated With Initial Low Early Warning Score and Increased Mortality.Critical care explorations · 2023Article
- Benchmarking of two bioinformatic workflows for the analysis of whole-genome sequenced Staphylococcus aureus collected from patients with suspected sepsis.BMC infectious diseases · 2023Observational
- Cerebral dysfunctions caused by sepsis during ageing.Nature reviews. Immunology · 2022Review
- Correlation of clinical sepsis definitions with microbiological characteristics in patients admitted through a sepsis alert system; a prospective cohort study.Annals of clinical microbiology and antimicrobials · 2022Article
- Identification of two robust subclasses of sepsis with both prognostic and therapeutic values based on machine learning analysis.Frontiers in immunology · 2022Article
- Increasing incidence and antimicrobial resistance in Escherichia coli bloodstream infections: a multinational population-based cohort study.Antimicrobial resistance and infection control · 2021Article
- Predicting mortality among septic patients presenting to the emergency department-a cross sectional analysis using machine learning.BMC emergency medicine · 2021Article
- Bacteremic sepsis leads to higher mortality when adjusting for confounders with propensity score matching.Scientific reports · 2021Article
- Early detection of sepsis using artificial intelligence: a scoping review protocol.Systematic reviews · 2021Article
- Impact of obesity on outcome of severe bacterial infections.PloS one · 2021Observational
- Genotypic Characterization of ClinicalFrontiers in microbiology · 2021Article
- Clinical Utilization of Blood and Urine Cultures and Incidences of Bacteremia and Bacteriuria in a Hospital in Thailand.Medical science monitor basic research · 2020Article
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3 authors at 2 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundSepsis is a major healthcare challenge globally. However, epidemiologic data based on population studies are scarce.
methodsDuring a 9-month prospective, population-based study, the Swedish Sepsis-2 criteria were used to investigate the incidence of community onset severe sepsis in adults aged ≥18 years (N = 2,196; mean age, 69; range, 18-102 years). All the patients who were admitted to the hospital and started on intravenous antibiotic treatment within 48 hours were evaluated. Retrospectively the incidence of sepsis according to Sepsis-3 criteria was calculated on this cohort.
resultsThe annual incidence of community onset severe sepsis in adults at first admission was 276/100,000 (95% CI, 254-300). The incidence increased more than 40-fold between the youngest and the oldest age group, and was higher for men than for women. The respiratory tract was the most common site of infection (41% of cases). Using the Sepsis-3 criteria, the annual incidence of sepsis was 838/100,000 (95% CI, 798-877), which is 3-fold higher than that of severe sepsis. The main reason for the discrepancy in incidences is the more generous criteria for respiratory dysfunction used in Sepsis-3. Bacteremia was seen in 13% of all the admitted patients, giving an incidence of 203/100,000/year (95%, CI 184-223), which is among the highest incidences reported.
conclusionsWe found a high incidence of community onset severe sepsis, albeit lower than that seen in previous Scandinavian studies. The incidence increased markedly with age of the patient. The incidence of community onset sepsis according to the Sepsis-3 definition is the highest reported to date. It is 3-fold higher than that for severe sepsis, due to more generous criteria for respiratory dysfunction. A very high incidence of bacteremia was noted, partly explained by the high frequency of blood cultures.
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