Evidence map›Paper›PMID 31804566›Full record

Observational studyScientific reports2019

HIV-Negative Cryptococcal Meningoencephalitis Results in a Persistent Frontal-Subcortical Syndrome.

Katherine Traino, Joseph Snow, Lillian Ham, Angela Summers, Laura Segalà, Talia Shirazi, Nadia Biassou, Anil Panackal, Seher Anjum, Kieren A Marr and 3 more

Open access · goldAbstract readComparative StudyObservational Study
In one paragraph

Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Host-membrane lipid composition controlsFrontiers in immunology · 2025
    Article
  3. Review
  4. Article
  5. Macropinocytosis as a potential mechanism driving neurotropism ofFrontiers in cellular and infection microbiology · 2023
    Review
  6. Article
  7. Review
  8. Outcomes in Previously Healthy Cryptococcal Meningoencephalitis Patients Treated With Pulse Taper Corticosteroids for Post-infectious Inflammatory Syndrome.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  9. Article
  10. Article
  11. Article
  12. Clinical Aspects of Immune Damage in Cryptococcosis.Current fungal infection reports · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Katherine TrainoNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Joseph SnowNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA. JosephSnow@mail.nih.gov.
Lillian HamNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Angela SummersNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Laura SegalàNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Talia ShiraziNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
Nadia BiassouRadiology and Imaging Sciences, Clinical Center, National Institutes of Health (NIH), Bethesda, MD, USA.
Anil PanackalLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Seher AnjumLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Kieren A MarrJohns Hopkins University Department of Medicine, Baltimore, MD, USA.
William C KreislNational Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA.
John E BennettLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA.
Peter R WilliamsonLaboratory of Clinical Immunology and Microbiology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA. williamsonpr@mail.nih.gov.
National Institute of Mental Health · USNational Institutes of Health · USNational Institute of Allergy and Infectious Diseases · USJohns Hopkins University · USNational Institutes of Health Clinical Center · US

Funding

Psychiatry Consultation Liaison Service ResearchZIAMH002922 · NIMH · NATIONAL INSTITUTE OF MENTAL HEALTH · PI PAO, MARYLAND · 2009 to 2025
$11.5M
Molecular Pathobiology of Cryptococcus neoformansZIAAI001123 · NIAID · NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES · PI WILLIAMSON, PETER · 2010 to 2025
$10.4M
Prospective Cohort Study of CryptococcosisU01AI109657 · NIAID · JOHNS HOPKINS UNIVERSITY · PI MARR, KIEREN A., WILLIAMSON, PETER RICHARD · 2013 to 2015
$1.9M
Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) AI001123Division of Intramural Research, National Institute of Allergy and Infectious Diseases (Division of Intramural Research of the NIAID) AI001124Intramural NIH HHS ZIA MH002922NIAID NIH HHS U01 AI109657
6 · The paper itself

Abstract

Twenty-seven previously healthy (of 36 consecutive eligible patients), HIV-negative cryptococcal meningoencephalitis (CM) patients underwent comprehensive neuropsychological evaluation during the late post-treatment period (1.3-4 years post diagnosis), assessing attention, language, learning, memory, visuospatial, executive function, information processing, psychomotor functioning, as well as mood symptoms. Seven of eight domains (all except attention) showed increased percentages of CM patients scoring in the less than 16

Indexed as

AdultAgedAged, 80 and overAlzheimer DiseaseAntifungal AgentsCognition DisordersCryptococcus neoformansDatasets as TopicExecutive FunctionFemaleFrontal LobeGliosisHIV-1HumansHydrocephalusMagnetic Resonance ImagingAntifungal Agents

Identifiers

PMID31804566
PMCPMC6895107
OpenAlexW2993980586

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.