Observational studyScientific reports2019
Inter-relationships between Gender, Frailty and 10-Year Survival in Older Italian Adults: an observational longitudinal study.
Observational study in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Exploring Nursing Interventions for Frail Individuals in Primary Care: A Systematic Review.International nursing review · 2025Pooled it
- Frailty and social support in older orthopedic surgical patients: a cross-sectional analysis.BMC geriatrics · 2026Article
- How aging may impact the failure to rescue after colorectal laparoscopic surgery. Analysis of 1000 patients in a single high-volume center.Updates in surgery · 2025Article
- Sex differences in the association between total energy intake and all-cause mortality among patients with metabolic dysfunction-associated steatotic liver disease.Scientific reports · 2025Article
- Longitudinal transitions in frailty and health-related quality of life investigated by a 5-year community study.Scientific reports · 2025Article
- Frailty in older adults patients: a prospective observational cohort study on subtype identification.European journal of medical research · 2025Observational
- The prevalence of frailty according to kidney function and its association with cognitive impairment, nutritional status, and clinical outcome.BMC nephrology · 2025Article
- Consumer Products Nerve Injuries Among Patients Products Presenting to United States Emergency Departments Between 2012 and 2021: A Nationwide Cohort.Open access emergency medicine : OAEM · 2025Article
- Sex Differences in the Association Between Inflammatory Biomarkers (Hs-CRP, IL-6, IL-10, TNF-α) and Frailty in Hospitalized Adults Aged ≥65 in Taizhou, China: A Cross-Sectional Study.Clinical interventions in aging · 2025Article
- Telepsychology revolution in the mental health care delivery: a global overview of emerging clinical and legal issues.Forensic sciences research · 2024Review
- Frailty or frailties: exploring frailty index subdimensions in the English Longitudinal Study of Ageing.Journal of epidemiology and community health · 2024Article
- Factors Associated with Frailty in Older Adults in Community and Nursing Home Settings: A Systematic Review with a Meta-Analysis.Journal of clinical medicine · 2024Review
- Cystic Fibrosis in Adults: A Paradigm of Frailty Syndrome? An Observational Study.Journal of clinical medicine · 2024Article
- Comprehensive, continuous, and compulsory monitoring of frailty in elderly.Journal of family medicine and primary care · 2023Article
- Potential Drug-Drug Interactions and Related Factors among Geriatric Outpatients of a Tertiary Care Hospital.Geriatrics (Basel, Switzerland) · 2023Article
- The prevalence and predictors of geriatric giants in community-dwelling older adults: a cross-sectional study from the Middle East.Scientific reports · 2023Article
- Long COVID: Clinical Framing, Biomarkers, and Therapeutic Approaches.Journal of personalized medicine · 2023Review
- Prevalence and association of frailty with SARS-CoV-2 infection in older adults in Southern Switzerland-Findings from the Corona Immunitas Ticino Study.BMC geriatrics · 2023Article
- Trajectories, Transitions, and Trends in Frailty among Older Adults: A Review.Annals of geriatric medicine and research · 2022Article
- Sex Differences in the Relation Between Frailty and Endothelial Dysfunction in Old Mice.The journals of gerontology. Series A, Biological sciences and medical sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aim of the present study was to assess the impact of gender on the relationship between long-term mortality and clinical frailty. In an observational, longitudinal study on 10-year mortality, we examined 1284 subjects. The Frailty Staging System was used to assess frailty. The Cox model was employed to assess variables independently associated with survival using a backward stepwise algorithm. To investigate the possible interactions between gender and the selected variables, an extension of the multivariable fractional polynomial algorithm was adopted. Women were more likely to be older, have a higher disability, present with more comorbidities, consume more drugs, be frail and have a higher rate of survival at the follow-up than were men. At the Cox multivariate analysis only age (HR 2.26), female gender (HR 0.43), and number of drugs (HR 1.57) were significant and independent factors associated with all-cause mortality. In the survival analyses, only frailty (vs no frailty) showed significant interaction with gender (p < 0.001, HR = 1.92). While the presence of frailty reduced the survival rate in women, no effect was observed in men. Importantly, frail women showed higher survival rates than did both frail and no frail men. The main finding of the present study is that gender shapes up the association between frailty and long-term survival rates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.