ArticleScientific reports2019
Molecular response of Deinococcus radiodurans to simulated microgravity explored by proteometabolomic approach.
Article in Scientific reports, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Systematic screening of 42 vancomycin-resistant Enterococcus faecium strains for resistance, biofilm, and desiccation in simulated microgravity.NPJ microgravity · 2024Article
- Article
- Microbiology of human spaceflight: microbial responses to mechanical forces that impact health and habitat sustainability.Microbiology and molecular biology reviews : MMBR · 2024Review
- Insights into the synthesis, engineering, and functions of microbial pigments inFrontiers in microbiology · 2024Review
- Biofilm formation of Pseudomonas aeruginosa in spaceflight is minimized on lubricant impregnated surfaces.NPJ microgravity · 2023Article
- Thiol Reductases inAntioxidants (Basel, Switzerland) · 2022Review
- Colony growth and biofilm formation ofFrontiers in microbiology · 2022Article
- Bridging the gap between microbial limits and extremes in space: space microbial biotechnology in the next 15 years.Microbial biotechnology · 2022Article
- Proteomic Response ofLife (Basel, Switzerland) · 2021Article
- Article
- Magnetic Field Induced Changes in the Shoot and Root Proteome of Barley (Frontiers in plant science · 2021Article
- Editorial: Astrobiology at the Interface: Interactions Between Biospheres, Geospheres, Hydrospheres and Atmospheres Under Planetary Conditions.Frontiers in microbiology · 2021Article
- Molecular repertoire of Deinococcus radiodurans after 1 year of exposure outside the International Space Station within the Tanpopo mission.Microbiome · 2020Article
- Molecular Mechanisms of Microbial Survivability in Outer Space: A Systems Biology Approach.Frontiers in microbiology · 2020Review
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Regarding future space exploration missions and long-term exposure experiments, a detailed investigation of all factors present in the outer space environment and their effects on organisms of all life kingdoms is advantageous. Influenced by the multiple factors of outer space, the extremophilic bacterium Deinococcus radiodurans has been long-termly exposed outside the International Space Station in frames of the Tanpopo orbital mission. The study presented here aims to elucidate molecular key components in D. radiodurans, which are responsible for recognition and adaptation to simulated microgravity. D. radiodurans cultures were grown for two days on plates in a fast-rotating 2-D clinostat to minimize sedimentation, thus simulating reduced gravity conditions. Subsequently, metabolites and proteins were extracted and measured with mass spectrometry-based techniques. Our results emphasize the importance of certain signal transducer proteins, which showed higher abundances in cells grown under reduced gravity. These proteins activate a cellular signal cascade, which leads to differences in gene expressions. Proteins involved in stress response, repair mechanisms and proteins connected to the extracellular milieu and the cell envelope showed an increased abundance under simulated microgravity. Focusing on the expression of these proteins might present a strategy of cells to adapt to microgravity conditions.
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